Table 3.

Kinetic models used to fit experimental drug release data.

Kinetic Model	Equation	Parameters
Higuchi equation-describes the Fickian diffusion of the drug	F = kHt1/2	Where F is the fractional drug release, kH is the kinetic constant and t is the release time.
Ritger-Peppas equation	F = k1tn	Where F is the fractional drug release, k1 is the kinetic constant, t is the release time, and n is the diffusional exponent
Peppas-Sahlin equation, which accounts for the coupled effects of Fickian diffusion and Case II transport	F = k1tm + k2t2m	The first term of this equation represents the contribution of Fickian diffusion, and the second term refers to the macromolecular relaxation contribution to the overall release process.
Peppas-Sahlin equation where exponent m fixed to 0.5	F = k1t1/2 + k2t	Where F is the fractional drug release, k1 and k2 are kinetic constants, and t is the release time.