Table 1.
Comparison of Liver function tests; CRP; cytokine levels; PGE2; TXA2; NF-κB p50, NF-κB p65 and NRP-1 in the studied groups.
| Healthy (n = 50) | Moderate Patients (n = 50) | Severe Patients (n = 50) | |
|---|---|---|---|
| ALT (U/I) | 16.35 ± 0.71 | 98.44 ± 7.64 ***,+++ | 152.72 ± 11.37 *** |
| AST(U/I) | 21.91 ± 1.00 | 83.54 ± 4.72 ***,+ | 100.82 ± 9.1 *** |
| Albumin (g/dl) | 4.00 ± 0.06 | 3.80 ± 0.14 ***,++ | 3.06 ± 0.05 *** |
| CRP(mg/dl) | 1.96 ± 0.20 | 51.75 ± 6.21 ***.+++ | 77.8 ± 3.33 *** |
| IL-1β (pg/mL) | 15.20 ± 0.51 | 35.57 ± 1.88 ***,+ | 29.96 ± 2.06 *** |
| IL-4 (pg/mL) | 4.07 ± 0.24 | 6.78 ± 0.27 *** | 6.48 ± 0.44 *** |
| IL-6 (pg/mL) | 10.37 ± 0.31 | 83.09 ± 5.25 ***,+++ | 110.37 ± 3.14 *** |
| IL-18 (pg/mL) | 116.08 ± 0.96 | 217.64 ± 7.47 *** | 229.68 ± 6.97 *** |
| IL-35 (pg/mL) | 76.30 ± 1.39 | 106.03 ± 1.57 *** | 105.05 ± 1.55 *** |
| PGE2(pg/mL) | 136.93 ± 1.45 | 260.44 ± 8.55 *** | 253.15 ± 8.78 *** |
| TXA2 (pg/mL) | 114.96 ± 0.73 | 241.74 ± 7.02 ***,+++ | 211.75 ± 6.91 *** |
| NF-κB p50 expression | 1.01 ± 0.002 | 2.29 ± 0.12 *** | 2.28 ± 0.09 *** |
| NF-κB p65 expression | 1.02 ± 0.003 | 4.38 ± 0.21 ***,+ | 3.89 ± 0.16 *** |
| NRP-1 expression | 1.01 ± 0.002 | 4.28 ± 0.16 *** | 3.98 ± 0.19 *** |
Data are expressed as mean ± standard error (SE). Values were considered significantly different at *** p < 0.001 versus healthy control and + p < 0.05; ++ p < 0.01 and +++ p < 0.001 versus severe group.