Table 2.
Summary of NBD-14189 pharmacokinetics parameters following a single IV bolus or PO administration of NBD-14189 in male Beagle Dogs.
| Dose Level (mg/kg) |
Analyte | Route | C0 (ng/mL) |
Tmax (h) |
Cmax (ng/mL) |
Tlast (h) |
AUClast (h*ng/mL) |
T 1/2 (h) |
AUCINF (h*ng/mL) |
Cl (mL/min/kg) |
Vz (L/kg) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NBD-14189 | IV Bolus | 1230 | 0.083 | 844 | 48 | 2600 | 20.0 | 3130 | 5.77 | 9.60 |
| 2 | NBD-14189 | PO | - | 3.3 | 181 | 48 | 3020 | 24.3 | 3820 | - | - |
Note: - = no data. Abbreviations: C0 = concentration immediately after initial; Tmax = time to reach Cmax; Cmax Observed maximum plasma or serum concentration after administration (first) injection; Tlast = Time of Last Measurable Concentration; T1/2 = time it takes for half the drug concentration to be eliminated; AUClast = area under the plasma concentration-time curve to the last measurable plasma concentration; AUCinf = a theoretical measure of the total exposure of the drug to the body from administration till all the drug is eliminated; Cl = a proportionality factor that relates the concentration of drug measured in the body to the rate of elimination; Vz = volume distribution. *, represent multiplication.