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. 2022 Oct 15;14(10):1981–2003. doi: 10.4251/wjgo.v14.i10.1981

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Construction of the cuproptosis-related long-chain non-coding RNA signature (CupRLSig) model. A: Sankey diagram showing the associations between cuproptosis-related long-chain non-coding RNAs (lncRNAs) and mRNAs; B: Forest plot showing 27 LncRNAs with hazard ratios (95% confidence intervals) and P values for association with HCC prognosis based on univariate Cox proportional-hazards analysis; C: Lasso coefficient profiles; D: Selection of the tuning parameter (lambda) in the Lasso model by ten-fold cross-validation based on minimum criteria for overall survival; E: Heatmap showing the correlations of the three lncRNAs incorporated into the cuproptosis-related long-chain non-coding RNA signature model (CupRLSig) model and 19 cuproptosis-related genes. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001.