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. 2022 Oct 15;14(10):1981–2003. doi: 10.4251/wjgo.v14.i10.1981

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Gene set functional annotation of differentially expressed genes and long-chain non-coding RNAs in high- and low-risk hepatocellular carcinoma groups. A: In gene ontology analysis, differentially expressed genes and long-chain non-coding RNAs (lncRNAs) were found to be most enriched in biological process terms mitotic nuclear division, mitotic sister chromatid segregation, nuclear division, chromosome segregation, and sister chromatid segregation; in cellular component terms condensed chromosomes, kinetochores, spindles, chromosomes, and condensed chromosomes; and in molecular function terms steroid hydroxylase activity, oxidoreductase activity, microtubule binding, aromatase activity, and tubulin binding; B: Differentially expressed genes and lncRNAs were found to be most enriched in the following five Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways: retinol metabolism, cytochrome P450 drug metabolism, cytochrome P450 xenobiotic metabolism, cell cycle, and chemical carcinogenesis-DNA adducts. BP: Biological process; CC: Cellular component; MF: Molecular function.