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. 2022 Sep 20;14(10):1985. doi: 10.3390/pharmaceutics14101985

Table 1.

Ka, kd, and KD(M) were calculated from each mAb by kinetic and steady-state affinity assay.

mAb Kinetic Affinity Steady State
ka (M−1.s−1) kd (s−1) KD (M) KD(M)
TT-117 6.33 × 103 ND ND 2.58 × 10−7
TT-120 3.65 × 105 7.70 × 10−5 2.11 × 10−10 2.41 × 10−8
TT-140 8.65 × 104 3.92 × 10−5 4.54 × 10−10 1.10 × 10−7
TT-143 6.61 × 103 ND ND 2.45 × 10−7
TT-243 7.68 × 103 ND ND 6.08 × 10−7

ND = not determined. There was no dissociation in the period of the 36,000 s.