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. 2022 Oct 1;10(10):1651. doi: 10.3390/vaccines10101651

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© 2022 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Brain, periventricular vasculitis. Cross section through a capillary vessel showing prominent signs of vasculitis. The endothelial cells (5) show swelling and vacuolation and are increased in number with enlargement of nuclei, indicative for activation. Furthermore, presence of mixed inflammatory cell infiltrates within the endothelial layer, consisting of lymphocytes (1), granulocytes (2), and histiocytes (4). The adjacent brain tissue also shows signs of inflammation (encephalitis) with presence of lymphocytes as well and activated microglia (3). H&E. Magnification: 200× (a) and 400× (b).