Table 1.
Flow cytometric panel for the identification of homing receptors expressed by antigen-specific lymphocyte population.
Marker | Receptor Type | Ligand | Function/Target Tissue |
---|---|---|---|
CD103 (ITGAE) | Integrin | E-cadherin | Entry into epithelial tissues including liver, skin [31] |
CD161 (KLRB1) | C-type lectin | LLT-1 | Entry into inflamed tissue, liver (IL-17 driven) [32] |
CD183 (CXCR3) | Chemokine receptor | CXCL9, CXCL10, CXCL11 | Entry into inflamed tissue, liver [33] |
CD185 (CXCR5) | Chemokine receptor | CXCL13 | Entry into lymph nodes, direction towards B cell-compartment (follicles/germinal centers) [34] |
CD186 (CXCR6) | Chemokine receptor | CXCL16 | Entry into inflamed tissue, liver [33] |
CD196 (CCR6) | Chemokine receptor | CCL20 | Entry into inflamed tissue, Th17, skin [35] |
CD197(CCR7) | Chemokine receptor | CCL19, CCL21 | Entry into secondary lymphoid organs [33,36], direction towards T cell compartments [34] |
CDw199 (CCR9) | Chemokine receptor | CCL25 | Entry into intestinal tissues [37] |
CCR10 | Chemokine receptor | CCL27, CCL28 | Entry into Skin [35] |