. 2022 Oct 18;15(10):1278. doi: 10.3390/ph15101278

Table 2.

Enzymatic activities of HDL-related enzymes measured in plasma or HDL.

Enzyme	Acute Inflammation	Chronic Inflammation
CETP	hSeps ¹: ↓ ^pl [340]	RA: ↑ ^HDL [341] SLE: ↑ ^pl [342] Psoriasis: ↓ ^pl [343] T2DM: ↓ ^pl [344,345] CKD: ↑ ^pl [346] NAFLD: ↑ ^pl [347,348]
Lp-PLA₂	Rab ²: ↓ ^HDL [22] hSurg ³: ↓ ^HDL [22] Mice ⁴: ↓ ^HDL [326]	RA: ↓ ^pl [331] ↑ ^pl [332] SLE ⁷: ↑ ^pl [328] Psoriasis: ↑ ^HDL [329,330] CKD: ↑ ^pl [349]
LCAT	hSeps ¹: ↓ ^pl [340] Ham ⁵: ↓ ^HDL [350] hEtox ⁶: ↓ ^pl [351]	RA: ↓ ^pl [106,352] Psoriasis: ↓ ^pl [353,354] T2DM: ↑ ^pl [355] ↓ ^pl [356] CKD: ↓ ^pl [357] NAFLD: ↑ ^pl [358]
Gpx3		RA: ↑ ^pl [359] ↓ ^pl [360,361] SLE: ↓ ^pl [362,363,364] Psoriasis: ↓ ^pl [365] PD: ↑ ^pl [366] ↓ ^pl [367,368] T2DM: ↑ ^pl [369] ↓ ^pl [370] CKD: ↓ ^pl [371,372] NAFLD: ↑ ^pl [373]
PON1	Rab ²: ↓ ^HDL [22] hSurg ³: ↓ ^HDL [22] Mice ⁴: ↓ ^HDL [326]	RA: ↓ ^HDL [341] ↓ ^pl [352] SLE: ↓ ^pl [342] Psoriasis: ↓ ^HDL [329] ↓ ^pl [353] PD: ↓ ^pl [374] T2DM: ↓ ^HDL [375] ↓ ^pl [376,377] CKD: ↓ ^pl [346,378] NAFLD: ↓ ^pl [347]
sPLA₂		RA, SLE: ↑ ^pl [379]

¹ sepsis in humans. ² croton oil-induced enflammation in New Zealand rabbit model. ³ acute inflammation after cardiac surgery in humans. ⁴ influenza induced inflammation in C57BL/6 mice. ⁵ LPS induced inflammation in Syrian hamster. ⁶ endotoxaemia in humans. ⁷ only in SLE women with CVD versus SLE controls without CVD. ^pl—activity measured in plasma. ^HDL—activity measured in HDL.