FIG. 5.

Comparison of the effects of i.m. and i.g. administrations of A/Johannesburg/97 HA on antigen-specific serum antibody responses. Shown are means ± SE of anti-A/Johannesburg/97 HA antibody titers in the sera of mice immunized i.m. with 1 μg of A/Johannesburg/97 HA unadjuvanted (IM) or immunized i.g. with 20-μg doses of A/Johannesburg/97 HA alone (HA Only) and in combination with either 1 or 10 μg of wtLT, 10 or 100 μg of LT-K63, or 10 or 100 μg of LT-R72 as indicated. Asterisks indicate groups whose values are significantly different from that of the i.m. immunized group (P ≤ 0.05).