Table 2.
The potential differential metabolites identified in serum which can be regulated by sinomenine (Δppm < 20).
| No. | RT (min) | Formula | Identification | Detected m/z | Change Trend (AOM/DSS vs. WT) |
Change Trend (AOM/DSS + SIN vs. AOM/DSS) |
|---|---|---|---|---|---|---|
| 1 | 10.42 | C25H47O12P | LysoPI (16:1) | 571.2961 | ↑ *** | ↓ *** |
| 2 | 6.62 | C18H39NO3 | Phytosphingosine | 318.2997 | ↓ *** | ↑ *** |
| 3 | 10.2 | C26H50NO7P | LysoPC (18:2) | 520.3393 | ↑ *** | ↓ ** |
| 4 | 12.23 | C26H52NO7P | LysoPC (18:1) | 522.3552 | ↑ *** | ↓ *** |
| 5 | 8.99 | C23H40NO7P | LysoPE (18:4) | 474.2596 | ↓ *** | ↑ ** |
| 6 | 21.52 | C20H34O2 | Dihomo-gamma-linolenic acid | 307.262 | ↑ *** | ↓ * |
| 7 | 10.23 | C30H50NO7P | LysoPC (22:6) | 568.3392 | ↑ *** | ↓ ** |
| 8 | 6.43 | C21H30O4 | 21-Deoxycortisol | 347.2217 | ↓ *** | ↑ ** |
| 9 | 8 | C18H39NO2 | Sphinganine | 302.3051 | ↓ *** | ↑ *** |
| 10 | 0.49 | C4H9N3O2 | Creatine | 132.0766 | ↓ *** | ↑ ** |
| 11 | 10.23 | C28H50NO7P | LysoPC (20:4) | 544.339 | ↑ *** | ↓ ** |
| 12 | 0.82 | C10H12N4O5 | Inosine | 269.089 | ↓ *** | ↑ ** |
| 13 | 10.75 | C25H46NO7P | LysoPE (20:3) | 504.3049 | ↑ *** | ↓ ** |
| 14 | 9.87 | C23H44NO7P | LysoPE (18:2) | 478.2923 | ↑ *** | ↓ ** |
| 15 | 0.51 | C8H17NO2 | 2-Aminocaprylic acid | 160.1333 | ↓ *** | ↑ ** |
| 16 | 21.01 | C22H34O2 | Docosapentaenoic acid | 331.263 | ↑ *** | ↓ * |
| 17 | 11.11 | C30H52NO7P | LysoPC (22:5) | 570.3522 | ↑ *** | ↓ ** |
| 18 | 11.38 | C28H52NO7P | LysoPC (20:3) | 546.3551 | ↑ ** | ↓ * |
| 19 | 9.96 | C25H44NO7P | LysoPE (20:4) | 502.2921 | ↑ ** | ↓ ** |
| 20 | 4.23 | C10H11NO3 | Phenylacetylglycine | 194.0805 | ↓ ** | ↑ ** |
| 21 | 9.98 | C27H44NO7P | LysoPE (22:6) | 526.2919 | ↑ ** | ↓ ** |
| 22 | 20.52 | C29H49O12P | LysoPI (20:4) | 621.3089 | ↓ * | ↑ *** |
| 23 | 0.82 | C5H4N4O | Hypoxanthine | 137.0467 | ↓ * | ↑ ** |
| 24 | 10.08 | C31H49O12P | LysoPI (22:6) | 643.2888 | ↑ *** | ↓ * |
| 25 | 4.6 | C8H15NO3 | Acetyl-DL-Leucine | 172.0972 | ↓ *** | ↑ * |
| 26 | 4.65 | C11H13NO3 | Acetylphenylalanine | 206.0823 | ↓ *** | ↑ * |
| 27 | 4.065 | C6H12O3 | Leucinic acid | 131.0715 | ↓ *** | ↑ * |
| 28 | 9.95 | C27H49O12P | LysoPI (18:2) | 595.2885 | ↑ ** | ↓ * |
| 29 | 4.72 | C7H8O4S | p-Cresol sulfate | 187.0071 | ↓ ** | ↑ ** |
| 30 | 4.78 | C11H11NO3 | Indolelactic acid | 204.0668 | ↓ ** | ↑ * |
| 31 | 0.91 | C4H8O3 | 3-Hydroxybutyric acid | 103.0403 | ↓ ** | ↑ ** |
| 32 | 0.52 | C4H6N4O3 | Allantoin | 157.0369 | ↓ ** | ↑ ** |
| 33 | 4.14 | C8H7NO4S | Indoxyl sulfate | 212.0011 | ↓ * | ↑ * |
| 34 | 2.1152 | C5H10O3 | 2-Hydroxyvalerate | 117.0561 | ↓ * | ↑ * |
The change trend of differentially expressed metabolites was labeled with (↑) up-regulation and (↓) down-regulation (*, p < 0.05; **, p < 0.01; ***, p < 0.001).