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CAN downregulated TLR-4/NF-κB signaling in CIS-administered rats. (A) Photomicrographs of sections in the lungs of rats showing increased expression of TLR-4, NF-κB p65, and iNOS in CIS-administered rats and a marked decrease in CAN-treated rats. (B) Image analysis showed that CAN significantly decreased TLR-4, NF-κB p65, and iNOS in CIS-administered rats. Data are Mean ± SEM, (n = 8). *** p < 0.001 vs. Control, and ## p < 0.01 and ### p < 0.001 vs. CIS.
