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Cytotoxic effect of genistein in HaCaT and SW620 cells.
| Compound | 24 h | 48 h | ||||
|---|---|---|---|---|---|---|
| IC50 (µM) | IC50 (µM) | SI | IC50 (µM) | IC50 (µM) | SI | |
| HaCat | SW620 | HaCat | SW620 | |||
| Genistein | >740 | 667.17 ± 33.52 | 1.34 | 225.01 ± 7.06 | 152.60 ± 19.13 | 1.47 |
| 5-FU | >962.10 | >962.10 | 0.9 | 18.5 ± 3.44 | 139.57 ± 19.09 | 0.1 |
The Inhibitory Concentration 50 (IC50) was found using dose–response curves. The selectivity index (SI) was calculated using the formula SI = IC50 Non-malignant cells (HaCat)/IC50 Tumor cells (SW620).
