Table 1.

Genes encoding cAMP signaling pathway components that develop driver mutations in human cancer. All abbreviations are defined in the text.

Gene	Pathway component	Tissue/organ involved	Tumor type
TSHR	GPCR	Thyroid	Adenomas
GPR101	GPCR	Pituitary	Somatotropinomas
GNAS	G protein alpha subunit	Adrenal cortex; Parathyroid	Adenomas
PDE8B	Phosphodiesterase	Adrenal cortex	Adenomas
PDE11A	Phosphodiesterase	Adrenal cortex; Testis Leydig/Sertoli cells; Germ cells	Adenomas; Germ cell tumors
PRKARA1	PKA, regulatory subunit	Adrenal cortex; Testis Sertoli cells; Pituitary	Adenomas; LCCSCT; Somatotropinomas
PRKACA	PKA, catalytic subunit	Adrenal cortex; Liver	Adenomas; Fibrolamellar hepatocellular cancer
PRKACB	PKA, catalytic subunit	Adrenal cortex	Adenomas
CREB	Transcription factor	Abdominal soft tissue; CNS	FET-CREB fusion tumors