. 2022 Sep 21;14(10):1990. doi: 10.3390/pharmaceutics14101990

Table 3.

The main characters of nanoparticles mentioned in this review, were summarized.

Mechanisms for Elevating Immunotherapy	Composition of NPs	PNMs	Target Cells	Main Results	Ref.
Enhancing uptake and presentation	PMSN@OVA-MPN	PMSN	DCs	PMSN@OVA-MPN prevented cancer cell proliferation and enhanced immune response	[72]
	UiO-OVA	Zircoium-based nMOF	APCs	UiO-OVA produce forceful antigens and effectively triggered CTLs	[73]
	W-TBP/CpG/PD-L1	Castionic nMOF	DCs	W-TBP NPs promoted antigen presentation	[74]
	LPSiNPs	PSi	B cells	LPSiNPs enhanced the activation of APCs and B cells	[75]
	IMHCS-OVA	IMHCSs	APCs	IMHCS-OVA promote the maturation of APCs	[76]
Tumor-targeted delivery	PSiPs-HER2	PSiNP	Cancer cells	PSiPs-HER2 achieved specific targeting and destruction of tumor cells	[77]
	MSN@polyphenol	MSN	Cancer cells	MSN@polyphenol achieved controlled molecule release	[78]
	CpG/ZANPs	MOFs	APCs	CpG/ZANPs targeted lymph nodes, and APCs, significantly inhibiting tumor proliferation	[79]
	CD@MSNs (carbon nanodots-based MSNs)	MSNs	TAMs, NKs	CD@MSNs combined with PTT could accumulate in the tumor and eliminated cancer cell metastasis	[80]
	LCP-II NPs	Calcium phosphate NPs	Cancer cells	The LCP-II NPs delivered drugs to tumor sites in a xenograft model	[81]
	PHNPs@DPA-S-S-BSA-MA@3-MA	PHNPs	TAMs	PHNPs exhibited efficiency for targeting TAMs, enhancing immune reaction, and preventing cancer development	[82]
Reversing immunosuppressive TME	Fe₃O₄-OVA nano-composites	Fe₃O₄ nanoparticles	TAMs, BMDC	The NPs stimulated the maturation of BMDCs and the activation TAMs to prevent cancer progress and development	[83]
	OX/IND-MSNP	MSNPs	APCs, cancer cells	The OX/IND-MSNP combined with immunotherapy leading to ICD and immune suppressive effects	[84]
	MIL-100 with MTO, hyaluronic acid	MOF (MIL-100)	Cancer cells	The NPs induced ICD and reversed the immunosuppressive effects	[85]
	IMD@Hf-DBP/αCD47	nMOFs	TAMs, cancer cells	Under X-ray irradiation, the NPs reversed the immunosuppressive effects	[86]
	ZIF-8/CpG ODNs	ZIF-8 NPs	TAMs	The NPs showed less cytotoxicity and enhanced the uptake of CpG ODNs in TAMs, and increased the levels of cytokines	[87]
	Ce6/MLT@SAB	Hybrid NPs	Cancer cells	The NPs combined with PDT further upregulated the level of CD4 + and CD8 + T cells in tumor sites and reduced the numbers of MDSCs	[88]
Multi-functionality	IMD@Hf-DBP/αCD47	nMOFs	TAMs, cancer cells	The NPs enhanced systematic immune responses through the combination of RT-RDT	[86]
	Cu-TBP	Cuporphyrin nMOF	Cancer cells	Cu-TBP elicited systemic anti-cancer immune responses by activating immune responses in primary and metastatic tumors	[89]
	MOF-OVA@CpG	MOF	APCs	Co-delivery of antigen and CpG triggered T cell activation and cytokine secretion, and inhibited cancer development	[90]
	COF-609	COF	Cancer cells	The study offered the first integration of PDT and immunotherapy by 3D COFs to inhibit cancer metastasis and recurrence and demonstrated a new way to design ICD inducers	[91]
	COF@ICG@OVA	COF	DCs	The NPs combined with NIR irradiation and a checkpoint inhibitor inhibited cancer progress and development	[92]
	FeSe₂-PE	FeSe₂ nanoflower	Cancer cells	The FeSe₂-PE-NPs were fabricated to achieve the on-demand release of H₂Se on NIR-II photoactivation to kill tumor cells	[67]
	H-MnO₂-PEG/C&D	Mesoporous MnO₂ nanoshells	Cancer cells	The NPs as a multifunctional theranostic platform regulated TME and PTT/PDT therapy and enhanced immunotherapy	[93]