Table 1.
Dong et al. [7] | Gale et al. [11] | Venturini et al. [15] | Kanburoglu et al. [16] | |
---|---|---|---|---|
Mild | Symptoms of acute upper respiratory tract infection or digestive symptoms | Fever and/or fatigue and/or upper airways symptoms without radiological/ultrasound findings | Upper respiratory tract infection or fever, no feeding difficulty and no obvious hypoxemia, and no risk of late neonatal sepsis | |
Moderate | Pneumonia without hypoxemia and shortness of breath Chest computed tomography abnormalities without clinical signs and symptoms |
Fever and/or fatigue and/or upper airways symptoms (cough or mild respiratory distress) and/or poor feeding and/or pneumonia identified with chest X-ray or ultrasound | Hospitalization due to feeding difficulty or risk of late neonatal sepsis, but no obvious hypoxemia or no need for nasal continuous positive airway pressure | |
Severe | Oxygen saturation is <92% with other hypoxia manifestations | At least two of the following: (1) any of hyperthermia, apnea, cough, tachypnoea, respiratory distress or recession, supplemental oxygen requirement, poor feeding or vomiting, or diarrhea; (2) any of low white blood cell count, low lymphocyte count, or raised C-reactive protein concentration; and (3) abnormal chest X-ray | Fever and cough, plus at least one of the following: (1) oxygen saturation on finger pulse <92% on room air; (2) severe respiratory distress, cyanosis, intermittent apnea; (3) fast breathing; (4) systemic symptoms: drowsiness, lethargy, seizures, dehydration | Oxygen saturation <92% or need for nasal continuous positive airway pressure |
Critical | Acute respiratory distress syndrome, respiratory failure, shock, encephalopathy, myocardial injury or heart failure, coagulation dysfunction, and acute kidney injury | Pediatric acute respiratory distress syndrome, sepsis-associated organ dysfunction, septic shock, coma | Mechanical ventilation or disseminated intravascular coagulopathy or multiple organ dysfunction |