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Schematic overview of the monkeypox virus life cycle and the mechanism of action of anti-poxvirus drugs. Like all poxviruses, monkeypox replicates in the cytoplasm of infected cells. Cidofovir and brincidofovir inhibit viral DNA polymerase; tecovirimat and NIOCH-14 prevents the formation of the cell-associated enveloped virion (CEV) and extracellular enveloped virion (EEV); and VIG prevents virion to infect new cells. The figure was created by Biorender.
