Table 1.

Systemic treatment options depending on genetic alterations.

Genetic Alteration	Possible Systemic Treatment
EGFR exon 19 deletion or L858R mutation	osimertinib
EGFR S768I, L861Q, G719X mutation	afatinib or osimertinib
EGFR insertion exon 20	amivantamab or mobocertinib
KRAS G12C mutation	sotorasib
ALK rearrangement	alectinib or lorlatinib or brigatinib
ROS1 rearrangement	entrectinib or crizotinib
NTRK 1/2/3 gene fusion	larotrectinib or entrectinib
MET exon14 skipping mutation	capmatinib or tepotinib
RET rearrangement	serpercatinib