Table 1.
Hydrodynamic radius (RH), polydispersity index (P.I.), zeta potential (ζ), Yield (%), encapsulation efficiency (E.E.) (%), and drug content (D.C.) (%) of CS NPs produced by ionotropic gelation of CS with SBE-β-CD (empty CS NPs) and the IDE/SBE-β-CD inclusion complex (1:2 molar ratio) (non-overloaded CS NPs). The values are expressed as the mean of six batches ± standard deviation (S.D.).
| Sample | Theoretical IDE Amount (mg) * | RH (nm) ± S.D. | P.I. ± S.D. | ζ (mV) ± S.D. | Yield (%) ± S.D. | E.E. (%) ± S.D. | D.C. (%) ± S.D. |
|---|---|---|---|---|---|---|---|
| Empty CS NPs | - | 138.28 ± 2.36 | 0.181 ± 0.056 | +27.3 ± 2.5 | 75.12 ± 1.82 | - | - |
| Non-overloaded CS NPs | 1 | 140.08 ± 3.71 | 0.169 ± 0.068 | +28.2 ± 1.9 | 53.2 ± 2.91 | 42.10 ± 2.03 | 2.93 ± 0.62 |
* It is the amount of IDE within the IDE/SBE-β-CD inclusion complex.