Table 2.
Hydrodynamic radius (RH), polydispersity index (P.I.), and zeta potential (ζ) of CS NPs prepared using the IDE/SBE-β-CD inclusion complex (1:2 molar ratio) as a gelling agent and overloaded with different concentrations of the IDE/HP-β-CD inclusion complex (1:2 molar ratio) (overloaded CS NPs). The values are expressed as the mean of six batches ± standard deviation (S.D.).
| Sample | Theoretical IDE Amount (mg) * | IDE/HP-β-CD Inclusion Complex Added to Polyanion Solution | IDE/HP-β-CD Inclusion Complex Added to Polycation Solution | ||||
|---|---|---|---|---|---|---|---|
| RH (nm) ± S.D. | P.I. ± S.D. | ζ (mV) ± S.D. | RH (nm) ± S.D. | P.I. ± S.D. | ζ (mV) ± S.D. | ||
| Overloaded CS NPs | 1.5 | 145.12 ± 1.36 | 0.206 ± 0.029 | +29.0 ± 1.9 | 141.56 ± 3.12 | 0.146 ± 0.051 | +30.2 ± 1.5 |
| 2 | 164.08 ± 0.80 | 0.231 ± 0.079 | +27.1 ± 0.9 | 139.08 ± 4.21 | 0.205 ± 0.029 | +28.8 ± 2.3 | |
| 2.5 | 171.10 ± 4.69 | 0.169 ± 0.091 | +28.1 ± 2.0 | 136.38 ± 0.91 | 0.224 ± 0.014 | +29.3 ± 0.9 | |
| 3 | 189.24 ± 2.71 | 0.112 ± 0.043 | 23.0 ± 1.7 | 146.94 ± 5.10 | 0.201 ± 0.058 | +30.1 ± 1.8 | |
* It is the sum of the drug complexed with SBE-β-CD and HP-β-CD.