Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 4;77:102214. doi: 10.1016/j.coi.2022.102214

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Elsevier Ltd. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

Current LNP technology in mRNA-based vaccines. (a) LNPs consist of an ionizable lipid, sterol, phospholipid, and a PEG lipid that together encapsulate and protect the mRNA core. Each lipid component has critical roles in LNP function. (b) The LNP-delivery system has been engineered to enable efficient cellular delivery of mRNA to cells and overcome certain physiological barriers, including protecting mRNA from degradation, uptake, and facilitating endosomal escape for subsequent translation of the encoded antigen(s).