Figure 4.

Self-report cognitive complaints and fatigue of patients treated for breast cancer with chemotherapy and their metabolic associations. Relative metabolic changes in the lateral occipital cortex preceded fatigue years later, but not cognitive complaints. After FDR-correction, this association disappeared. No associations were found for changes in the frontal cortex (paracingulate cortex, pericentral gyri) or basal ganglia (putamen), nor for absolute baseline metabolism in any of these regions or having received additional radiotherapy, endocrine therapy and/or HER2 therapy (n=64). Final linear models included chemo regime and were corrected for age, and years since treatment. Striped line = extreme cognitive complaints/fatigue, dotted line = cognitive complaints/fatigue. EC = 4 rounds of epirubicin 90 mg/m² + cyclophosphamide 600 mg/m²; FEC = 3-6 rounds of 500 mg/m² 5-fluorouracil and 4 rounds of epirubicin 100 mg/m² + cyclophosphamide 500 mg/m².