Table 2.

Robust mixed-effects modelling of time and treatment effects on relative brain glucose metabolism.

	Parameter	ß	(95% CI)	pFDR
Frontal cortex	Time	-0.350	(-0.451, -0.249)	1.1E-09
	Chemo regime	0.271	(-0.185, 0.727)	0.306
	Time by Chemo regime	0.215	(0.008, 0.423)	0.110
	EC only: Time	-0.435	(-0.568, -0.302)	8.2E-09
	FEC only: Time	-0.220	(-0.38, -0.059)	0.013
Parietal cortex	Time	0.273	(0.166, 0.38)	3.6E-06
	Chemo regime	-0.122	(-0.544, 0.299)	0.569
	Time by Chemo regime	0.045	(-0.172, 0.261)	0.686
	EC only: Time	0.256	(0.117, 0.395)	0.001
	FEC only: Time	0.301	(0.134, 0.468)	0.001
Temporal cortex	Time	0.076	(-0.074, 0.226)	0.320
	Chemo regime	0.309	(-0.172, 0.79)	0.306
	Time by Chemo regime	0.276	(-0.023, 0.575)	0.121
	EC only: Time	-0.031	(-0.224, 0.161)	0.751
	FEC only: Time	0.244	(0.015, 0.474)	0.048
Occipital cortex	Time	0.213	(0.007, 0.419)	0.056
	Chemo regime	-0.333	(-0.736, 0.071)	0.284
	Time by Chemo regime	-0.321	(-0.736, 0.093)	0.164
	EC only: Time	0.348	(0.076, 0.62)	0.022
	FEC only: Time	0.027	(-0.287, 0.341)	0.865
Insular cortex	Time	0.180	(0.059, 0.3)	0.007
	Chemo regime	0.381	(-0.089, 0.851)	0.284
	Time by Chemo regime	0.387	(0.151, 0.622)	0.008
	EC only: Time	0.036	(-0.115, 0.187)	0.751
	FEC only: Time	0.423	(0.241, 0.604)	4.9E-05

n = 324 scans of 183 subjects. T0 and EC treatments were set as reference levels; therefore, chemotherapy regime effects represent FEC treatment versus EC, and time effects represent changes from T0 to T1. Models were corrected for age, type of scanner and years since chemotherapy (see Supplementary Materials). Standardized ß values are presented so that estimates can be interpreted as effect sizes and CI – confidence interval for ß. Benjamini-Hochberg-corrected p-values are presented for comparing the five regions of interest.

Bold values means significant effect at the 5% level.