Table 3.
Significant clusters by whole-brain voxel-based analysis.
| kE | pclusterFWE-corrected | ppeak FWE-corrected | T | Peak coördinates (mm) | Harvard-Oxford (sub)cortical atlas region | Hemi | Contrast | Peak voxel difference | ||
|---|---|---|---|---|---|---|---|---|---|---|
| x | y | z | ||||||||
| 1102 | <.001 | <.001 | 8.03 | 4 | 52 | 4 | *paracingulate gyrus (frontal lobe) |
Both | T0 > T1 | -3.2 ± 3.9% |
| 684 | <.001 | <.001 | 7.20 | 24 | 4 | -12 | *putamen (subcortical) |
R | T1 > T0 | 3.2 ± 4.1% |
| 613 | <.001 | <.001 | 6.60 | -26 | 2 | -12 | *putamen (subcortical) |
L | T1 > T0 | 2.9 ± 4.4% |
| 525 | <.001 | <.001 | 8.97 | -50 | -80 | 2 | *lateral occipital cortex (occipital lobe) |
L | T1 > T0 | 2.9 ± 3.1% |
| 290 | <.001 | <.001 | 6.18 | 62 | -2 | 30 | *precentral gyrus (frontal lobe) |
R | T1 > T0 | 3.3 ± 5.0% |
| 225 | <.001 | <.001 | 7.04 | -62 | -4 | 26 | *postcentral gyrus (frontal lobe) |
L | T1 > T0 | 2.7 ± 3.6% |
| 1648 | <.001 | <.001 | 8.99 | 4 | 50 | 10 | paracingulate gyrus (frontal lobe) |
Both | EC: T0 > T1 |
-4.5 ± 3.8% |
| 330 | <.001 | <.001 | 6.14 | 26 | 2 | -10 | putamen (subcortical) |
R | EC: T1 > T0 |
4.0 ± 4.7% |
| 358 | <.001 | <.001 | 6.78 | -22 | 4 | -4 | putamen (subcortical) |
L | EC: T1 > T0 |
3.3 ± 4.3% |
| 320 | <.001 | <.001 | 7.42 | -50 | -78 | 0 | lateral occipital cortex (occipital lobe) |
L | EC: T1 > T0 |
3.1 ± 3.6% |
n = 282 scans of 141 subjects. Age and scanner are included in the statistical models as covariates. *Regions for which mean relative glucose metabolism was calculated for regression analysis.