Table 2. Time x group interaction regression coefficient from generalized estimating (GEE) and linear mixed effect models (LMM).

Outcome measures	Corrected GEE a	LMM v1 (without clustering/nesting) b	LMM v2 (with clustering/nesting) c
	Fasting plasma ceramides
Cer C14:0	-0.017	-0.017	-0.017
Cer C16:0	-0.023	-0.023	-0.023
Cer C18:0	-0.028	-0.028	-0.028
Cer C18:1	-0.005	-0.005	-0.005
Cer C20:0	-0.256	-0.256	-0.256
Cer C20:1	-0.001	-0.001	-0.001
Cer C22:0	-0.381	-0.381	-0.381
Cer C22:1	-0.004	-0.004	-0.004
Cer C24:0	-0.864	-0.864	-0.864
Cer C24:1	-0.325	-0.325	-0.325
T. Cer	-1.955	-1.955	-1.955
	Plasma sphingolipid bases
Sphinganine	-0.057	-0.057	-0.057
Sphingosine	-0.030	-0.030	-0.030
Dihydro-sphingosine-1-phosphate	-0.001	-0.001	-0.001
Sphingosine -1-phosphate	0.042	0.042	0.042
	Plasma amino acid metabolites
Arginine	17.623	17.802	17.831
Serine	-42.790	-42.044	-42.102
Proline	-75.779	-73.463	-73.439
Aspartate	-13.730	-13.730	-13.671
Cystathionine	-0.216	-0.158	-0.159
Sarcosine	-8.849	-8.849	-8.831
Ornithine	-37.477	-37.364	-37.293
Arginine Bioavailability Ratio	0.449	0.449	0.450
Lysine	-44.646	-43.479	-43.510
Alanine	-84.365	-82.806	-82.774
Glutamine	-73.613	-72.368	-73.116
Threonine	-43.160	-42.244	-42.785
Methionine	-2.551	-2.331	-2.320
Fischer ratio	0.057	0.065	0.067
Citrulline	-45.836	-45.637	-45.660
Histidine	1.297	1.470	1.471
Tryptophan	-3.279	-2.808	-2.823
Leucine	-9.533	-9.013	-8.944
Phenylalanine	-8.408	-8.357	-8.364

^a This model represents revised values after discussions with the authors of The Article. These coefficients are thus calculated with GEE model that was used by Mietus-Snyder et al., ignoring clustering and nesting.

^b This LMM model does not account for clustering and nesting.

^c This LMM model includes random intercepts for household units with adjusted degrees of freedom using between-within method.