Table 2.
Univariate and multivariable logistic regression for having a positive interferon gamma release assay test at latent tuberculosis infection screening.
| Variable | Observation (%) | Unadjusted OR (univariate analysis) | P value | Adjusted OR (multivariable analysis) | P value | |
| Age at IGRA test (years) | 1.01 (0.992–1.028) | 0.26 | 1.022 (1.0–1.05) | 0.05 | ||
| Year of HIV diagnosis | 0.99 (0.96–1.02) | 0.53 | 1.03 (0.99–1.07) | 0.23 | ||
| Sex | Male | 53/118 (44.9) | 1 | 1 | ||
| Female | 65/118 (55.1) | 1.71 (1.16–2.51) | 0.01 | 0.95 (0.62- 1.45) | 0.79 | |
| CD4+ cell count at IGRA test (cells/μl) | <200 | 2/118 (1.7) | 1 | 1 | ||
| 200–349 | 12/118 (10.2) | 1.63 (0.36–7.56) | 0.53 | 1.67 (0.35–7.97) | 0.52 | |
| 350–499 | 36/118 (30.5) | 3.87 (0.90–16.65) | 0.008 | 4.39 (0.99–19.53) | 0.05 | |
| ≥500 | 68/118 (57.6) | 3.09 (0.73–13.02) | 0.12 | 3.92 (0.89–17.12) | 0.07 | |
| Ethnicity | Blacka | 90/118 (76.3) | 1 | – | – | |
| South Asian | 17/118 (14.4) | 1.06 (0.60–1.88) | 0.84 | – | – | |
| White | 9/118 (7.6) | 0.11 (0.06–0.23) | <0.0001 | – | – | |
| Mixed/other | 2/118 (1.7) | 0.20 (0.05–0.86) | 0.03 | – | – | |
| UK birth status | Non-UK born | 108/118 (91.5) | 1 | – | – | |
| UK born | 10/118 (8.5) | 0.15 (0.08–0.30) | <0.0001 | – | – | |
| World Bank region of birth | Europe and Central Asia, North America and Latin America and Caribbean and Middle East and North Africab | 12/118 (10.2) | 1 | – | – | |
| South Asia and East Asia and Pacificc | 10/118 (8.5) | 5.79 (2.40–13.97) | <0.0001 | – | – | |
| Sub-Saharan Africa | 96/118 (81.4) | 7.80 (4.22–14.42) | <0.0001 | – | – | |
| TB incidence in country-of-birth [26], | Less than 50 of 100 000 population | 12/118 (10.2)¶ | 1 | 1 | ||
| 50–149/100 000 population | 12/118 (10.2) | 9.28 (3.94–21.85) | <0.0001 | 11.6 (4.79–28.10) | <0.0001 | |
| 150–249/100 000 population | 74/118 (62.7) | 7.46 (3.99–13.95) | <0.0001 | 8.26 (4.27–15.98) | <0.0001 | |
| 250–349/100 000 population | 11/118 (9.3) | 7.53 (3.16–17.92) | <0.0001 | 8.13 (3.33–19.86) | <0.0001 | |
| ≥350/100 000 population | 9/118 (7.6) | 5.62 (2.27–13.92) | <0.0001 | 6.16 (2.42–15.67) | <0.0001 | |
IGRA, interferon gamma release assay; OR, odds ratio.
a
All were black African; none were black Caribbean or black other.
b
All were from Europe and Central Asia; none were from Latin America and Caribbean, North America or the Middle East and North Africa.
c
Eight of 10 were from South Asia; 2/11 were from East Asia and Pacific region.