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. 2021 Sep 16;118(11):2506–2518. doi: 10.1093/cvr/cvab295

Figure 3.

Figure 3

Endothelial-specific Poldip2 knock-out decreases cytokine and chemoattractant levels in BAL in LPS-induced lung injury. LPS injection induced a significant increase in cytokine levels [IL-1β (A), IL-6 (B)] and chemoattractant molecules [CXCL1 (C), CXCL2 (D)] in BAL in Poldip2 EC+/+ mice. LPS injection also induced a significant increase in TNFα lung tissue levels (E) in Poldip2 EC+/+ mice. These effects were significantly blunted in Poldip2 EC−/− mice. Graphs represent averages ± SEM (BAL experiments: n = 5–6 for PBS controls, n = 13 in LPS treated mice; lung tissue experiment: n = 6 for PBS controls, n = 7 and 10 in LPS treated Poldip2 EC−/−, and Poldip2 EC+/+ mice, respectively). P < 0.0001, $$$P < 0.001, $$P < 0.01, compared to PBS injected Poldip2 EC+/+ mice, ##P < 0.01, #P < 0.05, compared to LPS injected Poldip2 EC+/+ mice (two-way ANOVA, with Tukey’s correction).