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. 2022 Oct 13;11:e81071. doi: 10.7554/eLife.81071

Figure 5. DA and reactivation-induced plasticity requires protein synthesis.

(A), Postsynaptic anisomycin prevents DA-dependent plasticity with postsynaptic burst stimulation (Ai), but leaves conventional t-LTD (Aii, gray trace) and t-LTP (black trace) intact. Summary of results (Aiii). All traces show an EPSP before (1) and 40 min after (2) pairing. Plots show averages of normalized EPSP slopes ± SEM.

Figure 5—source data 1. Normalized EPSP slopes, spike amplitudes and spike width of all recorded cells.

Figure 5.

Figure 5—figure supplement 1. Postsynaptic anisomycin (AM) does not affect baseline synaptic responses and action potential properties.

Figure 5—figure supplement 1.

(A), Stable baseline in presence of postsynaptic anisomycin and summary of result. Traces show an EPSP at the start of the recording (1) and 60 min later (2). Plot shows averages of normalized EPSP slopes ± SEM. (B), No significant change in spike amplitude with anisomycin compared to vehicle control. (C), No significant change in spike width with anisomycin compared to vehicle control.