Table 3.
HIS (SNP + GROUP) MODELS. SIGNIFICANT SNPs. HISPANIC.
| ADDITIVE | DOMINANT | RECESSIVE | HETHOM | ||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ADD | DOM | REC | HOM | HET | |||||||||||||||||||||||||
| CHROM | LOCUS | POS | ID | REF | ALT | A1 | A1_FREQ | OBS_CT | OR_CI95 | pvalue | qvalue | lfdr | OR_CI95 | pvalue | qvalue | lfdr | OR_CI95 | pvalue | qvalue | lfdr | OR_CI95 | pvalue | qvalue | lfdr | OR_CI95 | pvalue | qvalue | lfdr | |
| 1 | PROX1 | 213985913 | rs340874 | T | C | C | 0.353 | 468 | 0.78 (0.54-1.12) | 0.177 | 0.139 | 0.594 | 0.62 (0.38-1.00) | 0.049 | 0.023 | 0.079 | 1.06 (0.52-2.15) | 0.869 | 0.219 | 0.643 | 0.81 (0.39-1.70) | 0.585 | 0.371 | 0.858 | 0.56 (0.33-0.95) | 0.032 | 0.044 | 0.120 | |
| 2 | DPYSL5 | 26930006 | rs1371614 | C | T | T | 0.424 | 467 | 1.36 (0.98-1.88) | 0.069 | 0.064 | 0.229 | 1.77 (1.03-3.03) | 0.039 | 0.019 | 0.060 | 1.28 (0.72-2.27) | 0.407 | 0.129 | 0.521 | 1.79 (0.90-3.55) | 0.096 | 0.108 | 0.368 | 1.76 (0.99-3.12) | 0.054 | 0.069 | 0.202 | |
| 2 | GCKR | 27518370 | rs780094 | T | C | T | 0.331 | 465 | 0.80 (0.55-1.16) | 0.241 | 0.172 | 0.745 | 0.63 (0.39-1.02) | 0.063 | 0.029 | 0.107 | 1.20 (0.57-2.53) | 0.627 | 0.175 | 0.605 | 0.93 (0.43-2.01) | 0.852 | 0.443 | 0.858 | 0.57 (0.34-0.96) | 0.033 | 0.045 | 0.125 | |
| 2 | G6PC2 | 168917561 | rs563694 | C | A | C | 0.127 | 469 | 0.64 (0.36-1.14) | 0.132 | 0.111 | 0.460 | 0.54 (0.29-1.00) | 0.051 | 0.024 | 0.083 | 2.25 (0.55-9.11) | 0.258 | 0.093 | 0.417 | 1.96 (0.35-11.06) | 0.447 | 0.325 | 0.849 | 0.48 (0.24-0.95) | 0.034 | 0.046 | 0.126 | |
| 2 | IRS1 | 226203364 | rs2943634 | A | C | A | 0.204 | 466 | 0.65 (0.42-1.01) | 0.053 | 0.051 | 0.168 | 0.57 (0.33-0.98) | 0.041 | 0.020 | 0.064 | 0.61 (0.21-1.80) | 0.371 | 0.119 | 0.501 | 0.52 (0.18-1.56) | 0.247 | 0.223 | 0.730 | 0.58 (0.32-1.04) | 0.069 | 0.082 | 0.260 | |
| 3 | UBE2E2 | 23413299 | rs1496653 | A | G | G | 0.114 | 469 | 0.60 (0.33-1.09) | 0.095 | 0.084 | 0.330 | 0.56 (0.29-1.05) | 0.073 | 0.033 | 0.130 | 0.60 (0.12-2.92) | 0.526 | 0.158 | 0.573 | 0.54 (0.07-4.50) | 0.569 | 0.371 | 0.858 | 0.56 (0.28-1.11) | 0.097 | 0.108 | 0.371 | |
| 3 | IGF2BP2 | 185793899 | rs4402960 | G | T | T | 0.253 | 469 | 1.39 (0.96-2.01) | 0.085 | 0.077 | 0.291 | 1.36 (0.85-2.18) | 0.197 | 0.076 | 0.379 | 2.07 (0.95-4.51) | 0.067 | 0.030 | 0.114 | 2.26 (0.96-5.29) | 0.061 | 0.076 | 0.230 | 1.23 (0.74-2.04) | 0.428 | 0.314 | 0.845 | |
| 3 | IGF2BP2 | 185795604 | rs7651090 | A | G | G | 0.248 | 467 | 1.38 (0.94-2.02) | 0.096 | 0.084 | 0.333 | 1.35 (0.84-2.18) | 0.215 | 0.081 | 0.403 | 2.08 (0.87-4.97) | 0.099 | 0.043 | 0.180 | 2.28 (0.93-5.58) | 0.073 | 0.086 | 0.277 | 1.23 (0.75-2.04) | 0.412 | 0.311 | 0.841 | |
| 4 | WFS1 | 6288259 | rs4458523 | T | G | T | 0.315 | 463 | 0.80 (0.54-1.17) | 0.250 | 0.176 | 0.764 | 0.92 (0.57-1.49) | 0.730 | 0.198 | 0.632 | 0.31 (0.09-1.05) | 0.060 | 0.027 | 0.101 | 0.32 (0.09-1.11) | 0.073 | 0.086 | 0.278 | 1.06 (0.65-1.74) | 0.820 | 0.438 | 0.858 | |
| 5 | ANKRD55 | 56510924 | rs459193 | A | G | A | 0.234 | 467 | 1.35 (0.94-1.94) | 0.108 | 0.094 | 0.378 | 1.29 (0.80-2.09) | 0.304 | 0.108 | 0.485 | 2.18 (0.99-4.80) | 0.054 | 0.025 | 0.089 | 2.26 (1.00-5.11) | 0.050 | 0.064 | 0.185 | 1.11 (0.66-1.88) | 0.695 | 0.405 | 0.858 | |
| 5 | PCSK1 | 96393194 | rs6235 | C | G | G | 0.194 | 469 | 0.74 (0.48-1.16) | 0.196 | 0.149 | 0.641 | 0.85 (0.51-1.42) | 0.539 | 0.162 | 0.595 | 0.10 (0.01-1.79) | 0.118 | 0.049 | 0.218 | 0.10 (0.01-1.80) | 0.118 | 0.125 | 0.447 | 1.01 (0.61-1.69) | 0.965 | 0.468 | 0.858 | |
| 6 | CDKAL1 | 20686765 | rs9368222 | C | A | A | 0.226 | 469 | 1.50 (1.03-2.20) | 0.036 | 0.035 | 0.107 | 1.81 (1.13-2.90) | 0.014 | 0.011 | 0.022 | 1.17 (0.46-2.99) | 0.746 | 0.199 | 0.627 | 1.50 (0.55-4.15) | 0.430 | 0.314 | 0.846 | 1.86 (1.13-3.05) | 0.015 | 0.032 | 0.063 | |
| 6 | RSPO3 | 127131790 | rs2745353 | C | T | C | 0.401 | 469 | 0.80 (0.55-1.15) | 0.223 | 0.164 | 0.705 | 0.65 (0.40-1.05) | 0.081 | 0.036 | 0.149 | 1.00 (0.52-1.92) | 0.996 | 0.245 | 0.666 | 0.76 (0.37-1.57) | 0.465 | 0.331 | 0.852 | 0.62 (0.37-1.05) | 0.073 | 0.086 | 0.279 | |
| 7 | DGKB | 15024684 | rs2191349 | G | T | T | 0.410 | 468 | 1.42 (0.99-2.03) | 0.058 | 0.054 | 0.184 | 1.71 (0.99-2.96) | 0.056 | 0.026 | 0.092 | 1.39 (0.74-2.62) | 0.308 | 0.106 | 0.459 | 1.93 (0.91-4.07) | 0.085 | 0.097 | 0.324 | 1.65 (0.93-2.92) | 0.085 | 0.097 | 0.324 | |
| 7 | GRB10 | 50690548 | rs933360 | C | T | C | 0.364 | 468 | 1.38 (0.99-1.93) | 0.061 | 0.056 | 0.197 | 1.38 (0.84-2.27) | 0.201 | 0.077 | 0.386 | 1.81 (0.99-3.31) | 0.056 | 0.026 | 0.092 | 1.99 (1.02-3.90) | 0.045 | 0.059 | 0.167 | 1.20 (0.70-2.05) | 0.504 | 0.349 | 0.857 | |
| 9 | GLIS3 | 4287466 | rs7041847 | A | G | G | 0.421 | 468 | 0.70 (0.49-1.00) | 0.051 | 0.049 | 0.159 | 0.59 (0.36-0.96) | 0.034 | 0.017 | 0.052 | 0.72 (0.36-1.44) | 0.356 | 0.117 | 0.491 | 0.55 (0.26-1.15) | 0.112 | 0.121 | 0.425 | 0.61 (0.36-1.02) | 0.058 | 0.074 | 0.220 | |
| 9 | GLIS3 | 4293150 | rs10814916 | A | C | A | 0.465 | 466 | 0.74 (0.52-1.04) | 0.085 | 0.077 | 0.290 | 0.76 (0.46-1.26) | 0.291 | 0.105 | 0.476 | 0.54 (0.27-1.05) | 0.070 | 0.031 | 0.121 | 0.50 (0.24-1.04) | 0.064 | 0.078 | 0.244 | 0.88 (0.52-1.50) | 0.633 | 0.387 | 0.858 | |
| 10 | CUBN | 17114152 | rs1801222 | A | G | A | 0.262 | 468 | 0.83 (0.55-1.24) | 0.366 | 0.233 | 1.000 | 0.68 (0.41-1.10) | 0.116 | 0.050 | 0.231 | 1.57 (0.64-3.84) | 0.326 | 0.112 | 0.472 | 1.28 (0.51-3.21) | 0.594 | 0.374 | 0.858 | 0.60 (0.35-1.01) | 0.054 | 0.069 | 0.201 | |
| 10 | ADRA2A | 111282335 | rs10885122 | T | G | T | 0.183 | 469 | 1.31 (0.87-1.96) | 0.195 | 0.149 | 0.639 | 1.09 (0.67-1.79) | 0.718 | 0.197 | 0.631 | 3.69 (1.52-8.95) | 0.004 | 0.010 | 0.011 | 3.54 (1.38-9.07) | 0.009 | 0.032 | 0.045 | 0.86 (0.50-1.50) | 0.605 | 0.375 | 0.858 | |
| 11 | DUSP8 | 1675619 | rs2334499 | C | T | T | 0.455 | 467 | 1.33 (0.96-1.85) | 0.090 | 0.080 | 0.309 | 1.28 (0.75-2.17) | 0.370 | 0.124 | 0.526 | 1.71 (1.00-2.91) | 0.050 | 0.024 | 0.082 | 1.77 (0.93-3.36) | 0.080 | 0.093 | 0.305 | 1.06 (0.60-1.90) | 0.836 | 0.443 | 0.858 | |
| 11 | CRY2 | 45851540 | rs11605924 | A | C | C | 0.499 | 469 | 0.72 (0.51-1.01) | 0.057 | 0.054 | 0.182 | 0.84 (0.50-1.41) | 0.505 | 0.158 | 0.584 | 0.45 (0.24-0.84) | 0.012 | 0.010 | 0.022 | 0.46 (0.22-0.98) | 0.044 | 0.059 | 0.164 | 1.05 (0.60-1.84) | 0.863 | 0.443 | 0.858 | |
| 11 | MTNR1B | 92940662 | rs1387153 | C | T | T | 0.174 | 468 | 1.61 (1.06-2.43) | 0.025 | 0.025 | 0.074 | 1.65 (1.00-2.71) | 0.049 | 0.023 | 0.078 | 2.53 (0.84-7.68) | 0.101 | 0.043 | 0.183 | 2.91 (0.94-8.97) | 0.063 | 0.078 | 0.238 | 1.53 (0.91-2.58) | 0.109 | 0.120 | 0.415 | |
| 12 | P2RX2 | 132465032 | rs10747083 | G | A | G | 0.259 | 469 | 0.80 (0.53-1.21) | 0.298 | 0.198 | 0.868 | 0.67 (0.41-1.10) | 0.113 | 0.049 | 0.226 | 1.40 (0.54-3.62) | 0.482 | 0.147 | 0.556 | 1.16 (0.44-3.04) | 0.762 | 0.423 | 0.858 | 0.61 (0.36-1.03) | 0.065 | 0.078 | 0.245 | |
| 13 | PDX1 | 27917061 | rs2293941 | G | A | A | 0.295 | 469 | 1.09 (0.76-1.54) | 0.647 | 0.364 | 1.000 | 1.50 (0.92-2.43) | 0.103 | 0.045 | 0.201 | 0.46 (0.17-1.20) | 0.110 | 0.047 | 0.203 | 0.61 (0.22-1.65) | 0.325 | 0.264 | 0.802 | 1.79 (1.09-2.96) | 0.022 | 0.033 | 0.086 | |
| 19 | GIPR | 45693376 | rs2302593 | C | G | C | 0.414 | 467 | 1.48 (1.06-2.07) | 0.020 | 0.021 | 0.061 | 1.79 (1.04-3.07) | 0.034 | 0.017 | 0.051 | 1.62 (0.92-2.85) | 0.096 | 0.042 | 0.173 | 2.18 (1.11-4.28) | 0.024 | 0.035 | 0.091 | 1.64 (0.92-2.91) | 0.091 | 0.102 | 0.346 | |
| 21 | BACE2 | 41209710 | rs737288 | G | T | T | 0.208 | 467 | 1.21 (0.82-1.79) | 0.329 | 0.212 | 0.934 | 1.04 (0.63-1.72) | 0.869 | 0.227 | 0.634 | 2.56 (1.07-6.08) | 0.034 | 0.016 | 0.054 | 2.43 (1.01-5.86) | 0.049 | 0.064 | 0.181 | 0.84 (0.48-1.46) | 0.540 | 0.361 | 0.858 | |
| 21 | BACE2 | 41211811 | rs6517656 | G | A | A | 0.178 | 468 | 1.24 (0.84-1.84) | 0.277 | 0.190 | 0.824 | 1.15 (0.69-1.92) | 0.584 | 0.171 | 0.608 | 2.13 (0.87-5.23) | 0.100 | 0.043 | 0.182 | 2.12 (0.85-5.27) | 0.107 | 0.118 | 0.408 | 0.98 (0.56-1.73) | 0.951 | 0.466 | 0.858 |
Table that summarizes the most relevant results of the analysis of SNPs + Group models in Hispanic (HIS) ethnicity. ADD, Additive model; DOM, dominant model; REC, recessive model; HETHOM, heterozygous-homozygous model; CHROM, Chromosome code; LOCUS, Locus/Gene; POS, Base-pair coordinate [GRCh38]; ID, Variant ID; REF, Reference allele; ALT, Alternate allele; A1, Counted allele in logistic regression; A1_FREQ, minor allele frequency; OBS_CT, Number of samples in the regression; OR_CI95, odds ratio with 95% confidence interval.