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. 2022 Oct 28;15:117. doi: 10.1186/s13048-022-01051-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Serum metabolite variations associated with PCOS. a Differences in fungal structures as revealed by PCoA analysis. b Heatmap showing the relative abundance of the 40 metabolites screened by Kruskal–Wallis tests. c PLS-DA plot revealing the differential metabolite pattern between Healthy-LB and PCOS-LB. d PLS-DA plot revealing the differential metabolite pattern between Healthy-HB and PCOS-HB. e The distribution of the top 10 metabolites as VIP values ranked as shared by comparison between Healthy-LB and PCOS-LB and between Healthy-HB and PCOS-HB. f Characteristic metabolites based on LDA effect size (LEfSe) analysis between PCOS patients and healthy controls