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. 2022 Oct 28;15:117. doi: 10.1186/s13048-022-01051-8

Table 1.

Clinical characteristics baseline in the BMI-related healthy and PCOS groups

Parameter Characteristic Healthy-LB (n = 21) PCOS-LB (n = 22) p value FDR Healthy-HB (n = 20) PCOS-HB (n = 25) p value FDR Four groups p value Four groups FDR
Demographic characteristics Age (years) 28.53 ± 3.19 28.96 ± 3.87 0.6 0.832 29.9 ± 2.98 29.04 ± 3.89 0.283 0.498 0.555 0.666
BMI (kg/m2) 20.01 ± 1.83 20.68 ± 2.17 0.23 0.504 29.03 ± 3.06 28.19 ± 2.82 0.332 0.541 0.001 0.001
Liver function LDH (U/L) 174.2 ± 29.51 174.96 ± 44.35 0.942 0.972 183.8 ± 30.79 198.88 ± 30.71 0.121 0.272 0.013 0.025
AST (U/L) 20.2 ± 6.09 20.1 ± 5.73 0.808 0.972 19.62 ± 4.9 24.88 ± 10.51 0.071 0.209 0.121 0.166
ALT (U/L) 14.77 ± 7.95 18.19 ± 11.92 0.526 0.827 19.96 ± 10.31 32.35 ± 26.24 0.043 0.144 0.002 0.004
GGT (U/L) 20 ± 9.69 20.91 ± 9.58 0.551 0.832 21.97 ± 9.72 28.92 ± 14.32 0.044 0.144 0.021 0.039
ALP (U/L) 69.67 ± 16.8 69 ± 16.12 0.444 0.748 76.29 ± 16.11 78.04 ± 23.73 0.592 0.723 0.114 0.162
CHE (U/mL) 7.32 ± 1.49 7.96 ± 1.35 0.294 0.579 9.02 ± 1.32 9.6 ± 1.54 0.371 0.583 0.001 0.001
MAO (U/L) 3.29 ± 0.91 3 ± 1.12 0.303 0.579 5.42 ± 2.74 4.1 ± 1.47 0.128 0.272 0.001 0.001
AFU (U/L) 23.34 ± 4.34 27.23 ± 6.57 0.043 0.142 26.95 ± 5.69 29.32 ± 6.5 0.326 0.541 0.031 0.056
TP (g/L) 76.28 ± 4.51 77.01 ± 3.86 0.972 0.972 76.77 ± 4.77 76.56 ± 3.83 0.955 1 0.998 0.998
ALB (g/L) 44.1 ± 2.12 44.79 ± 1.94 0.338 0.619 45.69 ± 6.92 44.74 ± 2.14 0.53 0.707 0.676 0.782
GLB (g/L) 32.19 ± 3.03 32.22 ± 2.89 0.674 0.899 32.41 ± 3.92 31.82 ± 2.79 0.576 0.723 0.952 0.987
ALB/GLB 1.38 ± 0.11 1.4 ± 0.12 0.601 0.832 1.39 ± 0.18 1.41 ± 0.15 0.479 0.68 0.822 0.928
TBIL (μmol/L) 10.87 ± 4.56 10.94 ± 4.37 0.971 0.972 11.84 ± 5.65 10.45 ± 2.93 0.743 0.861 0.932 0.987
DBIL (μmol/L) 2.05 ± 0.94 1.96 ± 0.81 0.933 0.972 2.51 ± 2.4 1.77 ± 0.57 0.15 0.3 0.56 0.666
IBIL (μmol/L) 8.82 ± 3.7 8.99 ± 3.67 0.846 0.972 9.33 ± 3.75 8.67 ± 2.46 1 1 0.964 0.987
Renal function CO2 (mmol/L) 25.17 ± 2.48 26.22 ± 2.19 0.178 0.421 25.42 ± 7.61 25.62 ± 2.56 0.098 0.239 0.099 0.15
BUN (mmol/L) 4.8 ± 1.28 4.09 ± 0.71 0.032 0.12 4.74 ± 0.94 4.59 ± 1.14 0.418 0.634 0.067 0.114
Cr (μmol/L) 75.62 ± 7.22 71.19 ± 8.67 0.103 0.282 72.5 ± 11.08 71.68 ± 9.5 0.561 0.723 0.105 0.153
Metabolic index UA (μmol/L) 346.39 ± 89.7 355.47 ± 74.5 0.605 0.832 404.96 ± 138.48 428.22 ± 79.55 0.234 0.428 0.005 0.009
TC (mmol/L) 4.74 ± 0.83 4.74 ± 0.61 0.913 0.972 4.84 ± 0.72 4.8 ± 0.87 0.508 0.699 0.884 0.972
TG (mmol/L) 0.97 ± 0.39 1.06 ± 0.45 0.452 0.748 1.37 ± 0.65 1.43 ± 0.78 0.991 1 0.049 0.085
HDL-C (mmol/L) 1.58 ± 0.22 1.46 ± 0.29 0.096 0.282 1.1 ± 0.18 1.16 ± 0.16 0.226 0.428 0.001 0.001
LDL-C (mmol/L) 2.89 ± 0.66 2.94 ± 0.42 0.762 0.972 3.18 ± 0.58 3.15 ± 0.67 0.811 0.91 0.24 0.301
Sex hormone LH (mIU/mL) 6.12 ± 1.65 12.23 ± 7.73 0.004 0.027 3.17 ± 1.69 6.89 ± 3.29 0.001 0.001 0.001 0.001
FSH (mIU/mL) 4.58 ± 2.11 6.6 ± 2.04 0.001 0.015 5.64 ± 1.59 6.27 ± 1.68 0.085 0.225 0.002 0.003
LH/FSH 2.05 ± 3.15 1.93 ± 1.16 0.156 0.402 0.56 ± 0.2 1.23 ± 0.95 0.001 0.002 0.001 0.001
PRL (ng/mL) 26.15 ± 16.61 15.84 ± 7.79 0.015 0.064 20.5 ± 13.46 18.15 ± 10.28 0.624 0.742 0.092 0.146
E2 (pg/mL) 28.58 ± 18.32 69.08 ± 50.55 0.001 0.001 32.97 ± 14.52 44.13 ± 15.74 0.033 0.144 0.001 0.001
PROG (nmol/L) 0.9 ± 0.3 0.64 ± 0.37 0.008 0.039 0.64 ± 0.44 0.54 ± 0.48 0.087 0.225 0.001 0.003
Androgen AD (ng/mL) 1.2 ± 0.37 1.99 ± 0.9 0.004 0.027 0.87 ± 0.32 1.8 ± 0.65 0.001 0.001 0.001 0.001
TT (ng/mL) 0.31 ± 0.13 0.51 ± 0.28 0.033 0.12 0.19 ± 0.08 0.46 ± 0.23 0.001 0.001 0.001 0.001
DHEA (ng/mL) 10.11 ± 5.27 11.02 ± 8.88 0.953 0.972 5.57 ± 4.41 9.72 ± 4.71 0.005 0.031 0.004 0.008
FAI 1.83 ± 0.99 5.18 ± 3.35 0.001 0.002 2.32 ± 1.27 8.78 ± 4.93 0.001 0.001 0.001 0.001
SHBG (nmol/L) 68.1 ± 31.72 40.3 ± 17.5 0.002 0.022 32.91 ± 13.34 21.75 ± 11.81 0.005 0.031 0.001 0.001
Glucose tolerance G0 (mmol/L) 4.77 ± 0.38 5.16 ± 0.42 0.005 0.027 5.19 ± 0.69 5.67 ± 1.34 0.479 0.68 0.001 0.001
G120 (mmol/L) 5.76 ± 1.33 7.41 ± 2.44 0.007 0.039 6.98 ± 1.68 9.18 ± 4.09 0.023 0.123 0.001 0.001
Insulin I0 (mIU/L) 8.33 ± 3.65 12.36 ± 14.26 0.459 0.748 18.63 ± 9.21 18.52 ± 10.68 0.848 0.91 0.001 0.001
I120 (mIU/L) 52.3 ± 34.95 92.41 ± 78.14 0.046 0.142 106.17 ± 85.51 134.32 ± 71.02 0.13 0.272 0.001 0.002
HOMA-IR 1.8 ± 0.87 2.94 ± 3.73 0.269 0.564 4.27 ± 2.13 4.67 ± 2.7 0.847 0.91 0.001 0.001
Methylation FKBP5-Met1 51.86 ± 3.4 50.61 ± 2.41 0.182 0.421 54.59 ± 6.13 51.24 ± 4.78 0.041 0.144 0.093 0.146
FKBP5-Met2 80.41 ± 4.41 80.51 ± 4.07 0.857 0.972 84.81 ± 8.54 79.72 ± 7.3 0.046 0.144 0.161 0.208
FKBP5-Met 66.14 ± 3.64 65.56 ± 2.67 0.839 0.972 69.7 ± 7.06 65.48 ± 5.79 0.045 0.144 0.153 0.203

The data are shown as the mean ± SD

BMI Body mass index, LDH Lactate dehydrogenase, AST Aspartate aminotransferase, ALT Alanine aminotransferase, GGT Glutamyltransferase, ALP Alkaline phosphatase, CHE Cholinesterase, MAO Monoamine oxidase, AFU α-L-fucosidase, TP Total protein, ALB Albumin, GLB Globulin, TBIL Total bilirubin, DBIL Direct bilirubin, IBIL Indirect bilirubin, BUN urea nitrogen, Cr Creatinine, UA Uric acid, TG Triglycerides, TC Total cholesterol, HDL-C High-density lipoprotein cholesterol, LDL-C Low-density lipoprotein cholesterol, LH Luteinizing hormone, FSH Follicle stimulating hormone, PRL Prolactin, E2 Estrogen, PROG Progesterone, AD Androstenedione, TT Total testosterone, DHEA Dehydroepiandrosterone, FAI free androgen index, SHBG Sex hormone-binding globulin, G0 glucose level at fasting status, G120 Glucose level at 120 min after glucose load, I0 insulin level at fasting status, I120 insulin level at 120 min after glucose load, HOMA-IR homeostasis model assessment for IR, FKBP5-Met1 FKBP5 DNA methylation at CpG 35,657,180/hg19, FKBP5-Met2 FKBP5 DNA methylation at CpG 35,657,202/hg19, FKBP5-Met average of FKBP5 DNA methylation at CpG 35,657,180 and 35,657,202/hg19