Fig. 4. METTL3 enhances AML cell adhesion/migration in vitro and homing/engraftment in vivo.

A GSEA analyses of changed genes from RNA-seq and m⁶A-seq analysis of METTL3-overexpressing and control THP-1 cells (n = 3). B Images (left) and corresponding statistical results (right) showing that METTL3-overexpressing AML cells significantly improved the migration (upper panel) and adhesion (lower panel) of AML cells. P < 0.05 was considered significant, vs. the NC group, t test. Bar, 250 μm. C Flow cytometry was carried out on the BM and spleen of the xenograft recipient mice 16 h (homing) or 42 days (engraftment) after tail vein injection. P < 0.05 was considered significant, vs. the NC group, t test. n ≥ 3, mean ± SD values are shown for (B) and (C).