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. 2022 Oct 20;36(11):2586–2595. doi: 10.1038/s41375-022-01696-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A ITGA4 appears at a high frequency in multiple migration and adhesion pathways. B The improvement of migration and adhesion in METTL3-overexpressing AML cells can be partly reversed by an ITGA4 inhibitor (TR-14035). ***P < 0.001, ****P < 0.0001, vs. the NC group under DMSO treatment; ^#P < 0.05, ^##P < 0^.01, ^###P < 0.001, vs. the NC group under TR-14035 treatment; Ω, significant TR-14035 treatment effect; &, significant interaction effect; two-way ANOVA. Bar, 200 μm. C EdU incorporation assay showing that the improvement in the percentage of METTL3-overexpressing AML cells entering the proliferation cycle with IDA pressure can be partly reversed by TR-14035. *P < 0.05, **P < 0.01; ***P < 0.001; t test. n ≥ 3, mean ± SD values are shown for (B) and (C).