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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: J Invest Dermatol. 2022 Jun 9;142(11):2853–2863.e4. doi: 10.1016/j.jid.2022.04.028

Figure 4. RNAseq analyses of the age-associated changes in the cutaneous NMR transcriptome.

Figure 4.

(a) Functional annotation of the differentially expressed genes based on QIAGEN Ingenuity Pathway Analysis database and manually curated functional gene sub-categories. (b) A list of five top differentially expressed genes in each functional group (fold-change expression values are indicated by asterisks). (c) GO enrichment analysis showed significant over-representation of the extracellular matrix-associated genes, components of the insulin growth factor (IGF) signaling pathway, regulators of the glucose metabolism and cell proliferation.