Table 1.
Summary of diagnostic performance of cell free and exosomal miRNA-based biomarkers.
| miRNA | AUC (95% CI) | Accuracy (%) (95% CI) | PPV (%) (95% CI) | Sensitivity (%) (95% CI) | Specificity (%) (95% CI) | NPV (%) (95% CI) |
|---|---|---|---|---|---|---|
| cf-miR30c-5p | 0.79 (0.72-0.85) | 75 (69-81) | 91 (86-96) | 68 (59-77) | 88 (79-96) | 60 (53-67) |
| cf-let7e-5p | 0.67 (0.59-0.75) | 65 (59-72) | 79 (72-86) | 64 (56-72) | 69 (57-79) | 51 (44-58) |
| cf-miR340-5p | 0.67 (0.60-0.75) | 66 (60-73) | 87 (80-93) | 57 (48-66) | 84 (75-91) | 51 (46-58) |
| cf-miR223-3p | 0.73 (0.66-0.81) | 70 (64-76) | 77 (72-82) | 77 (69-84) | 58 (46-69) | 57 (49-67) |
| cf-miR26a-5p | 0.60 (0.52-0.68) | 57 (51-63) | 92 (84-98) | 37 (29-45) | 94 (88-99) | 45 (41-48) |
| cf-miR340-3p | 0.71 (0.64-0.79) | 69 (62-75) | 80 (75-86) | 69 (60-77) | 69 (58-79) | 54 (47-62) |
| cf-miR335-5p | 0.77 (0.71-0.84) | 73 (67-79) | 90 (85-95) | 66 (58-74) | 87 (78-94) | 58 (52-65) |
| cf-miR23b-3p | 0.57 (0.49-0.65) | 52 (47-57) | 92 (84-100) | 28 (21-36) | 96 (91-100) | 42 (39-45) |
| cf-miR142-3p | 0.65 (0.58-0.73) | 62 (57-69) | 92 (85-98) | 46 (37-55) | 93 (87-99) | 48 (44-53) |
| exo-miR200c-3p | 0.69 (0.62-0.77) | 61 (55-68) | 91 (84-97) | 45 (37-54) | 91 (85-97) | 47 (43-52) |
| exo-miR148a-3p | 0.59 (0.50-0.67) | 68 (61-73) | 71 (67-76) | 84 (77-90) | 37 (27-49) | 56 (43-69) |
| exo-miR216a-5p | 0.71 (0.64-0.78) | 65 (59-72) | 82 (75-88) | 60 (51-68) | 75 (64-85) | 50 (44-57) |
| exo-miR145-5p | 0.59 (0.51-0.67) | 62 (55-69) | 74 (68-79) | 65 (56-73) | 57 (45-69) | 47 (39-55) |
| exo-miR200b-3p | 0.87 (0.81-0.92) | 80 (74-85) | 94 (89-98) | 73 (65-81) | 91 (84-97) | 65 (58-72) |
| exo-miR143-3p | 0.63 (0.55-0.71) | 58 (51-65) | 79 (71-87) | 48 (40-57) | 76 (66-85) | 44 (39-50) |
| exo-miR34a-5p | 0.66 (0.58-0.74) | 66 (59-73) | 79 (73-86) | 65 (56-73) | 69 (57-79) | 51 (44-59) |
| exo-miR429 | 0.76 (0.68-0.83) | 70 (63-76) | 83 (77-89) | 68 (60-76) | 75 (64-85) | 56 (48-63) |
| exo-miR141-3p | 0.78 (0.72-0.85) | 72 (66-79) | 93 (87-98) | 62 (54-71) | 91 (84-97) | 57 (51-63) |
| exo-miR1260b | 0.60 (0.52-0.69) | 60 (53-67) | 74 (67-80) | 60 (52-69) | 60 (48-72) | 45 (38-52) |
| exo-miR145-3p | 0.80 (0.74-0.86) | 75 (69-81) | 91 (86-97) | 68 (60-76) | 88 (81-96) | 60 (54-67) |
| exo-miR216b-5p | 0.79 (0.72-0.85) | 74 (68-80) | 91 (85-96) | 66 (57-74) | 88 (79-96) | 59 (52-65) |
| exo-miR200a-3p | 0.76 (0.69-0.82) | 67 (61-73) | 89 (82-95) | 56 (48-65) | 87 (79-94) | 52 (47-58) |
| exo-miR1260a | 0.69 (0.61-0.76) | 67 (60-73) | 79 (72-85) | 68 (60-76) | 66 (54-76) | 53 (45-60) |
| exo-miR217-5p | 0.79 (0.73-0.85) | 72 (66-78) | 92 (86-97) | 63 (54-71) | 90 (82-97) | 57 (51-63) |
[miRNA: micro RNA; cf: cell-free miRNA; Exo: exosomal; AUC: area under the curve; PPV: positive predictive value; NPV: negative predictive value]