Table 3.

The diagnostic performance of CA19-9 alone and miRNA signature in combination with CA19-9 after fixing their specificity at 95% and 99%.

	Controls	Cancer	AUC (95% CI)	Sensitivity (%) (95% CI)	Sens@95%Spec (%) (95% CI)	Sens@99%Spec (%) (95% CI)
CA19-9 (All stages)	67	124	0.88 (0.83-0.92)	75 (68-82)	77 (69-85)	72 (62-81)
miRNA sig + CA19-9 (All stages)	67	124	0.99 (0.98-1.00)	94 (90-98)	95 (85-99)	86 (77-97)
CA19-9 (Early-stages)	67	91	0.86 (0.80-0.92)	71 (63-80)	74 (63-84)	68 (56-79)
miRNA sig + CA19-9 (Early-stages)	67	91	0.99 (0.98-1.00)	93 (88-0.98)	93 (81-0.99)	84 (74-0.96)

[miRNA: micro RNA; CA19-9: carbohydrate antigen 19-9; AUC: Area under the curve; Exo: exosomal; cf: cell-free; Sens@95%Spec: sensitivity after fixing the specificity at 95%; Sens@99%Spec: sensitivity after fixing the specificity at 99%; ROC: receiver operating characteristic]