Table 1.

Test performance of the novel liquid biopsy signature vs. fecal immunochemical test in clinical practice in a theoretical population of 100,000 individuals under age 50y being screened for EOCRC.

Screening test	Novel liquid biopsy signature		Fecal immunochemical test
Test performance	Sensitivity: 82%	Specificity: 86%	Sensitivity: 74%	Specificity: 96%
EOCRC prevalence	13 per 100,000 (0.013%)
Number of individuals	EOCRC +	No EOCRC	EOCRC +	No EOCRC
Test positive	11	13998	10	3999
Test negative	2	85989	3	95988
Number of patients with a positive test needing follow up colonoscopy	14009		4009
Percent of population with a positive test	14.01%		4.01%
Positive predictive value	0.08%		0.25%