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. 2022 Sep 23;122(12):2493–2514. doi: 10.1007/s00421-022-05041-y

Table 2.

Acute responses in circulating factors seen in exercise-, heat-, and hypoxia-based interventions in humans

Factor Exercise Heat Hypoxia
IL-1Rα Y1 Y5 Y (chronic)8
IL-1β Y1 ? ?
IL-6 Y2 Y5,6 Y(chronic)8
IL-8 Y2 Y5/N7 ?
IL-10 Y2 ? ?
VEGF Y3 N7 Y9
HSP72 Y4 Y6 Y10
TNFα Y1 N5,7 N9

Factors are marked dependent on whether an elevation (Y) or no change (N) is seen with a given intervention stimulus. If responses are only seen over chronic exposure (> 24-h) to a stimulus then this is also denoted (chronic). Factors are also marked if the response is not well understood (?)

IL interleukin, VEGF vascular endothelial growth factor, heat shock protein 72 HSP72, tumor necrosis factor alpha TNFα

References: 1(Ostrowski et al. 1999); 2(Kasapis and Thompson 2005); 3(Landers-Ramos et al. 2014); 4(Henstridge et al. 2016); 5(Leicht et al. 2015); 6(Faulkner et al. 2017); 7(Kuhlenhoelter et al. 2016); 8(Hartmann et al. 2000); 9(Burki and Tetenta 2014); 10(Taylor et al. 2010)