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. 2022 Oct 27;13:6385. doi: 10.1038/s41467-022-34083-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, b The immunohistochemical analyses of GPR97 expression in tissue sections of the early- a and late-stage b appendicitis. Reactivity of the anti-GPR97 mAb to GPR97 was shown as brownish staining. Scale bar, 100 μm. c The relative GPR97 staining intensities in tissue-infiltrating neutrophils of the early- (n = 11) and late-stage (n = 16) appendicitis tissues. Data are means ± SEM and p value was determined by one-sided unpaired student’s t-test. d Flow cytometry analyses of surface GPR97 levels of gated neutrophils of HC (n = 8) and bacterial sepsis patients (n = 5). Data are means ± SEM and p value was determined by two-sided unpaired student’s t-test. e, f Flow cytometry analyses of surface GPR97 levels of gated neutrophils of HC (n = 5 in e, 6 in f) and patients based on the disease category (GPA n = 8, MPA n = 6) e and status (remission n = 10, active n = 7) f. g The positive correlation of GPR97 levels with the ANCA titers of GPA (n = 8) and MPA (n = 6) patients. Data are means ± SEM and p value was determined by one-way ANOVA. HC healthy control, GPA granulomatosis with polyangiitis, MPA microscopic polyangiitis. Source data are provided in the Source Data file.