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. 2022 Apr 22;29(11):2163–2176. doi: 10.1038/s41418-022-01005-z

Fig. 7. Summary of the preB-I preleukemic state induced by IRF4 deficiency.

Fig. 7

Cartoon summarizing the findings for IRF4 deficient compared to wt B lymphopoiesis. B lineage (lin) cells are less responsive to BMSC-derived CXCL12 due to reduced surface CXCR4 expression (1). Irf4−/− preB-I cells exhibit impaired differentiation and IL-7 dependent hyperproliferation (2). Irf4−/− preB cells escape into the periphery (3), where a combination of IL-7 deprivation and danger-associated molecular patterns (such as LPS) might induce AID expression (4), fueling mutagenesis.