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. 2022 Oct 27;12:18063. doi: 10.1038/s41598-022-22252-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Protein–protein interactions network with DEGs for brain metastasis in SCLC. Up and down-regulated candidate genes are coloured on the scale of logFC. Log2FC is an indicator of the expression level of these genes since logFC = 3.75 for the most up-regulated gene in BM SCLC patients and logFC = − 3.75 for the most down-regulated gene. The nodes' size characterises the connectivity degree for identifying the critical hub genes (CAT and APP). Unconnected nodes are trimmed from the figure.