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. 2022 Oct 27;12:18063. doi: 10.1038/s41598-022-22252-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Prognostic values of two hub genes in the brain metastases from SCLC patients. Kaplan–Meier survival analysis of 2 hub genes in patients with small-cell lung cancer. The prognostic value of (A) APP and (B) CAT for determining the prognostic value of APP and CAT mRNA expression were evaluated using the Kaplan–Meier plotter. The Affymetrix IDs of the genes are as follows: 200602_at (APP) and 201432_at (CAT). Logrank test for Kaplan–Meier analysis reveals the p-value for both APP and CAT survival analysis. APP and CAT were specifically represented among lung metastasis samples. The patients survive probability with a high expression of hub genes indicated as red-line, and patients survive probability with a low expression of hub genes indicated as black-line. The high and low-expression cohorts were divided by the median survival time.