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. 2022 May 9;29(11):2203–2217. doi: 10.1038/s41418-022-01010-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Analysis of RUNX family expression in normal and breast cancer by using GEO and TCGA database. B Analysis of RUNX family expression in breast cancer by using GEO database. C Kaplan–Meier survival analysis of the relationship between survival time and expression of RUNX family using an online tool (http://kmplot.com/analysis/). D Expression of RUNX family in normal and breast cancer cell lines. E Expression of RUNX family in breast cancer and adjacent tissues (n = 6). Results were presented as mean ± SEM. F Knockdown efficiencies of RUNX1, RUNX2, and RUNX3 were verified by RT-qPCR. G Growth curve assays were performed in MDA-MB-231 and SUM159 cells transfected with siRNA against RUNX1, RUNX2, and RUNX3. H EdU assays were performed in RUNX family-deficient MDA-MB-231 and SUM159 cells and corresponding statistical analysis. Representative images in each group were shown. Results were presented as mean ± SD. Two-tailed unpaired t test, *p < 0.05, **p < 0.01.