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. 2022 Oct 27;13:6411. doi: 10.1038/s41467-022-34097-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Cryo-EM densities and models are colored in shades of blue for the human disome and red for the yeast disome (EMD-4427 [https://www.ebi.ac.uk/emdb/EMD-14181], PDB ID: 6I7O [10.2210/pdb7QVP/pdb]) in all panels. Focused views with indicated rotations refer to panel A left. A Overlay of the cryo-EM densities of the human and the yeast disomes shows an apparent 18° rotation of the colliding ribosome with respect to the leading ribosome in yeast compared to the human disome. B, C Detailed view of the single human inter-ribosomal 40S–60S contact area. D, E Detail of the yeast-specific inter-ribosomal 40S–60S contact via the expansion segment ES6b of the colliding ribosome (ES6b-2). F, G Detail of differences in the head-to-head contact area.