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. 2022 Oct 27;5:1137. doi: 10.1038/s42003-022-04066-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic representation of a sagittal E13.5 mouse brain section and the corresponding coronal cuts shown in I and II. Boxed areas in red are shown for rostral (I) and caudal (II) levels. The position of the septum is indicated in yellow. b YFP/GFP expression in forebrain germinal regions (ventricular zone, VZ) of three lines used for fate mapping. Cre recombination can be detected in the neocortex (Emx1-Cre;GFP), the septum (Zic4-Cre;YFP) and the AEP/POA (Shh-Cre;YFP). Immunolabelling for Gsh2 and Nkx-2-1 delineates the subpallium and the MGE/POA regions, respectively. Scale bar: 200 μm. c Transgenic lines with expression in the subventricular (SVZ) and mantle zones. In Lhx6-Cre;YFP, YFP labelling spans the MGE SVZ and mantle. YFP^+ve neurons initiating their migration toward the cortex are indicated with white arrows. TdT expression is detected in presumptive immature cholinergic forebrain neurons in Lhx7-Cre;TdT. YFP immunoreactivity can be detected in the mantle zone of the septum in Bsx-Cre;YFP mice. Ventral boundaries are indicated by a dashed white line. AEP anterior entopeduncular region, MGE medial ganglionic eminence, POA preoptic area. Scale bar: 200 μm. d, e Summary of VZ- and SVZ/mantle-expressing Cre lines used in this study. The area of expression for each transgenic line is identified by a different colour. The same colour coding is used in subsequent fate-mapping Figs. 3–5.