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. 2022 Oct 28;25(11):105455. doi: 10.1016/j.isci.2022.105455

Figure 2.

Figure 2

Vaccine-induced neutralizing activity against WH1, Delta, and Omicron in PAD patients

(A) NAb ID50 titers elicited in CVID (n = 12, black circles), unPAD (n = 9, black triangles), other PADs (CID: n = 1, open triangles and TID: n = 1, open circles), and HC groups (n = 10, black diamonds) against SARS-CoV-2 WH1, Delta, and Omicron variants at w8.

(B) Time course of vaccine-induced neutralizing antibodies in all groups against WH1 variant.

(C–E) Levels of NAbs at w24 in PAD patients and HC group against WH1, Delta, and Omicron variants, respectively. NAb titers against Delta (D) and Omicron (E) elicited in CVID, unPAD, other PADs, and HCs.

(F) NAb levels after three vaccine doses (w28) in PAD patients compared to those elicited after two doses (w8) in HCs. ID50: Half maximal inhibitory dilution. In (A,C, and F), Box-whiskers plots showing Min, Max, median and interquartile range are shown.

Data was analyzed using Dunn’s Multiple Comparison Test (A, C and F), and Wilcoxon signed rank test (B, D and E). ∗p<0.05; ∗∗p<0.01; ∗∗∗p<0.001; ∗∗∗∗p < 0.0001. Horizontal dotted line indicates limit of detection.