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. 2022 Oct 28;25(11):105455. doi: 10.1016/j.isci.2022.105455

Figure 4.

Figure 4

Vaccine-induced SARS-CoV-2-specific IFN-ɣ T cell responses

(A) Number of antigen-specific IFN-ɣ-producing T cells in CVID (n = 12, black circles), unPAD (n = 9, black triangles), other PADs (CID: n = 1, open triangles and TID: n = 1, open circles), and HC groups (n = 10, black diamonds) per 100.000 cells.

(B–E) Antigen-specific IFN-ɣ-producing T cells fold change respect to basal (w0). Comparison of Spike-specific spot-forming cells among CVID, unPAD, and HC groups at w8 (C), w24 versus w28 (D), and w28 versus w8 (E). In (C–E), Box-whiskers plots showing Min, Max, median and interquartile range are shown. (A and B) Horizontal dotted line indicates limit of detection and in (B) lines indicate median.

Data in (A and B) were analyzed using Wilcoxon signed rank test. Data in (C–E) were analyzed using Dunn’s Multiple Comparison Test. ∗p<0.05; ∗∗p<0.01; ∗∗∗p < 0.001.