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. 2022 Oct 28;321:167–181. doi: 10.1016/j.jad.2022.10.040

Table 3.

Most frequently reported risk factors for mental health symptomsa.

Type Details Studies Numbers
Sociodemographic factor Female (Abdulghani et al., 2020; AbuDujain et al., 2021; Aftab et al., 2021; AlJhani et al., 2021; Alkhamees et al., 2020; Alkwai, 2021; Allah et al., 2021; Alotiby et al., 2021; Alrashed et al., 2021; Alshammari et al., 2021; Biswas et al., 2021; Capdevila-Gaudens et al., 2021; Çimen et al., 2021; Cockburn et al., 2022; Domínguez-González et al., 2022; Duan et al., 2022; Eleftheriou et al., 2021; Esmat et al., 2021; Essadek et al., 2022; Essangri et al., 2021; Goweda et al., 2020; Gupta et al., 2021; Halperin et al., 2021; Hassnain et al., 2021; Huarcaya-Victoria et al., 2021; Khurram et al., 2020; Kuman Tunçel et al., 2021; Lee et al., 2021; Lingyu et al., 2021; Menon et al., 2021; Muhammad Alfareed Zafar et al., 2020; Nakhostin-Ansari et al., 2020; Natalia and Syakurah, 2021; Ni et al., 2021; Nihmath Nisha et al., 2020; Nikas et al., 2022; Pedraz-Petrozzi et al., 2021; Pelaccia et al., 2021; Pelissier et al., 2021; Perissotto et al., 2021; Puranachaikere et al., 2021; Roka et al., 2020; Rolland et al., 2022a, Rolland et al., 2022b; Safarini et al., 2021; Saravia-Bartra et al., 2020; Seetan et al., 2021; Shrestha et al., 2021; Simic et al., 2021; Soltan et al., 2021; Teixeira et al., 2021; Toubasi et al., 2021; Vala et al., 2020; Wang et al., 2021; Xiao et al., 2020; Xie et al., 2020; Yuan et al., 2021; Tian et al., 2021; Jiang et al., 2020; Xing et al., 2020; Zheng et al., 2021b; Zheng et al., 2021c) 62
Male (Chang et al., 2021; Gao et al., 2021; Kumar et al., 2021; Xie et al., 2020, Xie et al., 2021; Feng et al., 2021; Zhang et al., 2020b; Jin et al., 2021; Ma et al., 2021) 9
Be younger (Abdulghani et al., 2020; AlJhani et al., 2021; Eid et al., 2021; Lee et al., 2021; Mishra et al., 2021; Muhammad Alfareed Zafar et al., 2020; Pedraz-Petrozzi et al., 2021; Rolland et al., 2022a; Seetan et al., 2021; Yang et al., 2021; Zhang et al., 2021c) 11
Be older (Allah et al., 2021; Kumar et al., 2021; Periasamy et al., 2021; Risal et al., 2020; Xie et al., 2021; Zheng et al., 2021a) 6
Living in rural (Cao et al., 2020; Gao et al., 2021; Liu et al., 2021a; Meng et al., 2021; Xiao et al., 2021; Zheng et al., 2021a; Zhang et al., 2020c; Wang et al., 2022; Jin et al., 2021) 9
Economic instability (Allah et al., 2021; Cao et al., 2020; Capdevila-Gaudens et al., 2021; Çimen et al., 2021; Huarcaya-Victoria et al., 2021; Khurram et al., 2020; Kumar et al., 2020; Nishimura et al., 2021; Puranachaikere et al., 2021; Rolland et al., 2022b; Simic et al., 2021; Xiao et al., 2021; Ye et al., 2020; Jiang et al., 2020) 14
Not living home or housing stress (Dahanayake et al., 2021; Elhadi et al., 2020; Nikas et al., 2022; Teixeira et al., 2021) 4
Physiological factor Psychiatric disorders history or current psychiatric disorder (Aftab et al., 2021; AlJhani et al., 2021; Chootong et al., 2022; Çimen et al., 2021; Crisol-Deza et al., 2022; Domínguez-González et al., 2022; Essangri et al., 2021; Forycka et al., 2022; Guo et al., 2021; Mishra et al., 2022; Nishimura et al., 2021; Pelissier et al., 2021; Puranachaikere et al., 2021; Risal et al., 2020; Soltan et al., 2021; Teixeira et al., 2021; Zhang et al., 2021c; Wang et al., 2022) 18
Negative coping style (Lu et al., 2022; Mishra et al., 2021; Saali et al., 2021; Yuan et al., 2021; Zhao et al., 2021; Xia et al., 2022; Zheng et al., 2021b) 7
Low resilience (Forycka et al., 2022; Saali et al., 2021; Zhao et al., 2022, Zhao et al., 2021; Xu et al., 2021) 5
Education factor Junior student or preclinical studentsb (Adhikari et al., 2021; Ali et al., 2020; AlJhani et al., 2021; Alshammari et al., 2021; Büssing et al., 2021; Capdevila-Gaudens et al., 2021; Chan et al., 2022; Chootong et al., 2022; Çimen et al., 2021; Essadek et al., 2022; Essangri et al., 2021; Goweda et al., 2020; Guse et al., 2021; Halperin et al., 2021; Huarcaya-Victoria et al., 2021; Ismail et al., 2021; Kolcu and Başer Kolcu, 2021; Kostina et al., 2021; Lee et al., 2021; Lingyu et al., 2021; Natalia and Syakurah, 2021; Perissotto et al., 2021; Romic et al., 2021; Saeed and Javed, 2021; Sandoval et al., 2021; Seetan et al., 2021; Shrestha et al., 2021; Simic et al., 2021; Teixeira et al., 2021; Zhao et al., 2021; Zhang et al., 2020c) 31
Senior students or clinical studentsc (Elhadi et al., 2020; Hassnain et al., 2021; Xiao et al., 2021; Xie et al., 2020; Zis et al., 2021; Xu et al., 2021; Jiang et al., 2020) 7
3rd year student (Abdulghani et al., 2020; Chang et al., 2021; Guo et al., 2021; Jin et al., 2021; Gao et al., 2020) 5
Low academic performance or heavy academic burden (AlJhani et al., 2021; Allah et al., 2021; Atta and Almilaibary, 2022; Bolatov et al., 2020; Capdevila-Gaudens et al., 2021; Cardoso et al., 2022; Chang et al., 2021; Esmat et al., 2021; Gao et al., 2021; Nakhostin-Ansari et al., 2020; Safa et al., 2021; Xiao et al., 2021; Yang et al., 2022a; Yuan et al., 2021; Zhong et al., 2021; Ren et al., 2021; Feng et al., 2021; Jiang et al., 2020; Chen et al., 2020) 19
Decreased willingness in medicine learning (Deng et al., 2021a; Khalafallah et al., 2021; Peng et al., 2022; Wang et al., 2020; Yang et al., 2022b; Tian et al., 2021; Zheng et al., 2021c) 7
Being postgraduated (Duan et al., 2022; Meng et al., 2021; Wang et al., 2020; Xiao et al., 2020; Zhan et al., 2020; Liu et al., 2020; Liu et al., 2021b) 7
Fear of education or career impairment (Bilgi et al., 2021; Cao et al., 2020; Gruba et al., 2021; Guse et al., 2021; Huarcaya-Victoria et al., 2021; Khalafallah et al., 2021; Kuman Tunçel et al., 2021; Kumar et al., 2020; Saali et al., 2021; Teixeira et al., 2021; Wang et al., 2020; Xie et al., 2020) 12
Online learning trouble or dissatisfaction (Abdulghani et al., 2020; AlJhani et al., 2021; Chang et al., 2021; Dwivedi et al., 2020; Ecker et al., 2022; Forycka et al., 2022; Nikas et al., 2022; Nishimura et al., 2021; Pelissier et al., 2021; Potapova et al., 2021; Teixeira et al., 2021; Wang et al., 2021; Zhao et al., 2021; Jin et al., 2021) 14
Clinical duties (Aftab et al., 2021; Alrashed et al., 2021; Wang et al., 2020) 3
COVID-19 factor Infected with COVID-19 or symptoms of COVID-19 (Eleftheriou et al., 2021; Essadek et al., 2022; Kolcu and Başer Kolcu, 2021; Meng et al., 2021; Nakhostin-Ansari et al., 2020; Tahir et al., 2021; Wu et al., 2020; Zhang et al., 2020a) 8
Fear of infection with COVID-19 or health worry (Bilgi et al., 2021; Gruba et al., 2021; Kuman Tunçel et al., 2021; Safa et al., 2021; Saraswathi et al., 2020; Simic et al., 2021; Teixeira et al., 2021; Wang et al., 2021, Wang et al., 2020; Wu et al., 2020; Zhang et al., 2020a; Ma et al., 2021) 12
Covid-19 related worry on daily life (Cuschieri and Calleja Agius, 2020; Guo et al., 2021; Safa et al., 2021; Simic et al., 2021; Ren et al., 2021) 5
Negative perception of lockdown or COVID-19 (Abdulghani et al., 2020; Essadek et al., 2022; Kumar et al., 2020; Pelaccia et al., 2021; Saguem et al., 2021; Xiong et al., 2021) 6
Low health literacy or little knowledge of COVID-19 (Gao et al., 2021; Jindal et al., 2020; Muhammad Alfareed Zafar et al., 2020; Xie et al., 2021; Ye et al., 2020; Zhong et al., 2021; Gao et al., 2020) 7
High degree of focusing on COVID-19 (Muhammad Alfareed Zafar et al., 2020; Meng et al., 2021; Xie et al., 2020; Wu et al., 2020; Gao et al., 2020; Yang et al., 2021) 6
Being in high-epidemic COVID-19 area or relatives infected with COVID-19 (Aftab et al., 2021; Bilgi et al., 2021; Cao et al., 2020; Çimen et al., 2021; Eleftheriou et al., 2021; Essangri et al., 2021; Halperin et al., 2021; Huarcaya-Victoria et al., 2021; Kolcu and Başer Kolcu, 2021; Kuman Tunçel et al., 2021; Lee et al., 2021; Lingyu et al., 2021; Lu et al., 2022; Meng et al., 2021; Moayed et al., 2021; Risal et al., 2020; Saraswathi et al., 2020; Tahir et al., 2021; Teixeira et al., 2021; Xiao et al., 2020; Xie et al., 2021; Zhang et al., 2021b; Zhang et al., 2021c; Zhang et al., 2020a; Zhang et al., 2020c; Ma et al., 2021) 26
Health factor Current health status or physical distress history (Capdevila-Gaudens et al., 2021; Çimen et al., 2021; Mishra et al., 2021; Natalia and Syakurah, 2021; Risal et al., 2020; Sandoval et al., 2021; Yang et al., 2021; Zhang et al., 2021b; Zhang et al., 2022; Feng et al., 2021; Wang et al., 2022) 11
Lifestyle factor Problematic smartphone/internet use or much screen time or smartphone/internet addiction (Biswas et al., 2021; Dhamija et al., 2021; Goweda et al., 2020; Milasauskiene et al., 2021; Mishra et al., 2022, Mishra et al., 2021; Tahir et al., 2021; Telgote et al., 2021; Xie et al., 2021; Zhang et al., 2021a) 10
Smoking or other substance use (Capdevila-Gaudens et al., 2021; Cardoso et al., 2022; Gao et al., 2021; Pelissier et al., 2021; Safarini et al., 2021; Saguem et al., 2021) 6
Unhealthy lifestyle (such as irregular diet, irregular sleep, and soft-drink consumption) (Gao et al., 2021; Mishra et al., 2021; Shafique et al., 2021; Teixeira et al., 2021; Xiao et al., 2020, Xiao et al., 2021; Zhang et al., 2021c; Miu and Y, 2021) 8
Low physical activity (Cardoso et al., 2022; Mendes et al., 2021; Menon et al., 2021; Mishra et al., 2022; Saguem et al., 2021; Souza et al., 2021; Toubasi et al., 2021; Xiao et al., 2021; Zhang et al., 2021c; Chen et al., 2020; Lei et al., 2021) 11
Relational factor Family relationship (Capdevila-Gaudens et al., 2021; Chang et al., 2021; Lingyu et al., 2021; Simic et al., 2021; Song et al., 2021; Ren et al., 2021; Wang et al., 2022; Jiang et al., 2020; Jin et al., 2021) 9
Living alone or loneliness (Allah et al., 2021; Bolatov et al., 2020; Cao et al., 2020; Elhadi et al., 2020; Lee et al., 2021; Lu et al., 2022; Menon et al., 2021; Rolland et al., 2022a; Ren et al., 2021; Feng et al., 2021; Xia et al., 2022; Zhang et al., 2021d; Zheng et al., 2021c; Chen et al., 2020) 14
Low social support (Al-Hasani et al., 2021; Cao et al., 2020; Capdevila-Gaudens et al., 2021; Lu et al., 2022; Pelissier et al., 2021; Puranachaikere et al., 2021; Saali et al., 2021; Zhong et al., 2021; Zhang et al., 2020c; Zheng et al., 2021b) 10
Predictors of response to trauma History of traumatic events (such as traffic accidents or sexual harassments) (Pelissier et al., 2021; Rolland et al., 2022b; Saali et al., 2021; Soltan et al., 2021) 4
a

Factors which were reported as statistically significant associated factors in at least k = 3 studies were defined as frequently reported associated factors.

b

Junior students refer to 1st year or 2nd year medical students.

c

Senior students refer to 4th year or 5th year medical students.

d

Compared with undergraduate students.