Table 3.
Association between SNPs and grade 2–3 and grade 3 hypertension, diarrhea, hand- foot syndrome (HFS), and composite toxicity adjusted for age (continuous), gender, race/ethnicity, and treatment arm in CALGB 80802 (validation set) under a dominant genetic model.
| SNP | MAF | grade 2–3 OR (95% CI) | grade 2–3 p-value | grade 3 OR (95% CI) | grade 3 p-value |
|---|---|---|---|---|---|
|
| |||||
| Hypertension | |||||
| rs444904 (G>A) in PIK3R5 | 0.15 | 0.42 (0.19–0.92) | 0.029 | 0.39 (0.10–1.49) | 0.17 |
|
| |||||
| Diarrhea | |||||
| rs917881 (G>A) in EGFR | 0.15 | 0.32 (0.13–0.80) | 0.015 | 0.39 (0.10–1.48) | 0.17 |
|
| |||||
| Dermatologic toxicity (HFS) | |||||
| rs12366035 (C>T) in VEGFB | 0.25 | 1.31 (0.66–2.59) | 0.44 | 1.75 (0.70–4.38) | 0.23 |
|
| |||||
| Composite toxicity | |||||
| rs12366035 (C>T) in VEGFB | 0.25 | 0.80 (0.43–1.49) | 0.47 | 1.18 (0.60–2.35) | 0.63 |
| rs4035887 (G>A) in EPAS1 | 0.44 | 1.42 (0.74–2.74) | 0.29 | 1.32 (0.62–2.79) | 0.47 |
| rs4864950 (T>A) in KDR | 0.25 | 1.39 (0.75–2.58) | 0.30 | 2.03 (1.02–4.06) | 0.044 |
The SNP in bold is the one replicated with the same direction of effect, CI: confidence interval, HFS: hand-foot syndrome, MAF: minor allele frequency, OR: odds ratio, SNP: single nucleotide polymorphism.