Table 2.

Comparison of pain relief and responder status before and after stimulation holiday

	Preholiday	1-month postholiday	3-month postholiday	6-month postholiday
Continuous outcome analysis					Mean difference (95% CI)*	P value*
Sample size, n	35	40	34	25
Mean percentage pain relief (SD)†	8.7 (13.0)	41.2 (27.5)	40.8 (27.3)	34.0 (27.8)	30.6 (21.9 to 39.3)	<0.001

Categorical outcome analysis					OR (95% CI)*	P value*
Sample size, n	35	40	34	25
≥50% relief in pain intensity, n (%)	0 (0)	23 (57.5)	21 (61.8)	11 (44.0)	‡	<0.001
≥30% relief in pain intensity, n (%)	6 (17.1)	30 (75.0)	23 (67.6)	13 (52.0)	14.5 (4.7 to 45.0)	<0.001

*Pairwise comparison between preholiday and 1-month postholiday pain relief and responder status is reported here. Pairwise comparisons between preholiday vs 3-month postholiday metrics and preholiday vs 6-month postholiday metrics are reported in the text. For the continuous outcome analysis, mean percentage pain relief was compared before and after stimulation holiday using paired t-test. For the categorical outcome analysis, responder status frequency based on various pain relief thresholds (≥50% and ≥30%) was compared before and after stimulation holiday using Fisher’s exact test.

†Mean percentage pain relief is presented for all patients at each study time point (preholiday, 1-month postholiday, 3-month postholiday, and 6-month postholiday). When conducting pairwise statistical comparisons between preholiday mean relief and postholiday mean relief, patients who did not report relief at both time points were omitted from analysis. Thus, the mean values in this table include all patients who reported percentage pain relief for that time point. This differs from the mean values reported in the text, which includes only patients who reported percentage pain relief at both time points that were included in the paired statistical comparison.

‡OR is infinite. This is because there were zero patients who experienced ≥50% relief before stimulation holiday.